node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEFSEC | PSTK | ENSP00000254730 | ENSP00000357882 | eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP | phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity) | 0.911 |
EEFSEC | SARS | ENSP00000254730 | ENSP00000234677 | eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) | 0.608 |
EEFSEC | SECISBP2 | ENSP00000254730 | ENSP00000364965 | eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP | SECIS binding protein 2; Binds to the SECIS element in the 3’-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB | 0.994 |
EEFSEC | SEPHS1 | ENSP00000254730 | ENSP00000367893 | eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP | selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP | 0.935 |
EEFSEC | SEPHS2 | ENSP00000254730 | ENSP00000426234 | eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP | selenophosphate synthetase 2; Synthesizes selenophosphate from selenide and ATP | 0.868 |
EEFSEC | SEPSECS | ENSP00000254730 | ENSP00000371535 | eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP | Sep (O-phosphoserine) tRNA-Sec (selenocysteine) tRNA synthase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis | 0.807 |
EEFSEC | TRNAU1AP | ENSP00000254730 | ENSP00000362936 | eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP | tRNA selenocysteine 1 associated protein 1; Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity) | 0.941 |
EEFSEC | VIMP | ENSP00000254730 | ENSP00000381282 | eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP | VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination | 0.818 |
PSTK | EEFSEC | ENSP00000357882 | ENSP00000254730 | phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity) | eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP | 0.911 |
PSTK | SARS | ENSP00000357882 | ENSP00000234677 | phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity) | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) | 0.973 |
PSTK | SARS2 | ENSP00000357882 | ENSP00000472847 | phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity) | seryl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) | 0.904 |
PSTK | SECISBP2 | ENSP00000357882 | ENSP00000364965 | phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity) | SECIS binding protein 2; Binds to the SECIS element in the 3’-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB | 0.710 |
PSTK | SELK | ENSP00000357882 | ENSP00000418813 | phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity) | selenoprotein K | 0.516 |
PSTK | SEPHS1 | ENSP00000357882 | ENSP00000367893 | phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity) | selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP | 0.606 |
PSTK | SEPHS2 | ENSP00000357882 | ENSP00000426234 | phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity) | selenophosphate synthetase 2; Synthesizes selenophosphate from selenide and ATP | 0.681 |
PSTK | SEPSECS | ENSP00000357882 | ENSP00000371535 | phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity) | Sep (O-phosphoserine) tRNA-Sec (selenocysteine) tRNA synthase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis | 0.990 |
PSTK | TRNAU1AP | ENSP00000357882 | ENSP00000362936 | phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity) | tRNA selenocysteine 1 associated protein 1; Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity) | 0.819 |
PSTK | VIMP | ENSP00000357882 | ENSP00000381282 | phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity) | VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination | 0.584 |
SARS | EEFSEC | ENSP00000234677 | ENSP00000254730 | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) | eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP | 0.608 |
SARS | PSTK | ENSP00000234677 | ENSP00000357882 | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) | phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity) | 0.973 |