DMBT1 protein (Homo sapiens) - STRING network view

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Score

DMBT1

deleted in malignant brain tumors 1 (2413 aa)

Predicted Functional Partners:

SFTPD

0.989

LGALS3

0.840

STAT1

0.800

STAT6

0.800

ZNF845

0.750

ZNF320

0.747

SFTPA1

0.652

ZNF525

0.610

CDK6

0.551

CAV1

0.504

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV1	DMBT1	ENSP00000339191	ENSP00000357905	caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway	deleted in malignant brain tumors 1	0.504
CAV1	STAT1	ENSP00000339191	ENSP00000354394	caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway	signal transducer and activator of transcription 1, 91kDa	0.740
CDK6	DMBT1	ENSP00000265734	ENSP00000357905	cyclin-dependent kinase 6; Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cel [...]	deleted in malignant brain tumors 1	0.551
DMBT1	CAV1	ENSP00000357905	ENSP00000339191	deleted in malignant brain tumors 1	caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway	0.504
DMBT1	CDK6	ENSP00000357905	ENSP00000265734	deleted in malignant brain tumors 1	cyclin-dependent kinase 6; Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cel [...]	0.551
DMBT1	LGALS3	ENSP00000357905	ENSP00000254301	deleted in malignant brain tumors 1	lectin, galactoside-binding, soluble, 3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus- acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells	0.840
DMBT1	SFTPA1	ENSP00000357905	ENSP00000397082	deleted in malignant brain tumors 1	surfactant protein A1	0.652
DMBT1	SFTPD	ENSP00000357905	ENSP00000361366	deleted in malignant brain tumors 1	surfactant protein D; Contributes to the lung’s defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties	0.989
DMBT1	STAT1	ENSP00000357905	ENSP00000354394	deleted in malignant brain tumors 1	signal transducer and activator of transcription 1, 91kDa	0.800
DMBT1	STAT6	ENSP00000357905	ENSP00000300134	deleted in malignant brain tumors 1	signal transducer and activator of transcription 6, interleukin-4 induced; Carries out a dual function- signal transduction and activation of transcription. Involved in interleukin-4 signalling	0.800
DMBT1	ZNF320	ENSP00000357905	ENSP00000375660	deleted in malignant brain tumors 1	zinc finger protein 320; May be involved in transcriptional regulation	0.747
DMBT1	ZNF525	ENSP00000357905	ENSP00000417696	deleted in malignant brain tumors 1	zinc finger protein 525; May be involved in transcriptional regulation	0.610
DMBT1	ZNF845	ENSP00000357905	ENSP00000388311	deleted in malignant brain tumors 1	zinc finger protein 845; May be involved in transcriptional regulation (By similarity)	0.750
LGALS3	DMBT1	ENSP00000254301	ENSP00000357905	lectin, galactoside-binding, soluble, 3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus- acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells	deleted in malignant brain tumors 1	0.840
SFTPA1	DMBT1	ENSP00000397082	ENSP00000357905	surfactant protein A1	deleted in malignant brain tumors 1	0.652
SFTPA1	SFTPD	ENSP00000397082	ENSP00000361366	surfactant protein A1	surfactant protein D; Contributes to the lung’s defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties	0.665
SFTPD	DMBT1	ENSP00000361366	ENSP00000357905	surfactant protein D; Contributes to the lung’s defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties	deleted in malignant brain tumors 1	0.989
SFTPD	SFTPA1	ENSP00000361366	ENSP00000397082	surfactant protein D; Contributes to the lung’s defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties	surfactant protein A1	0.665
STAT1	CAV1	ENSP00000354394	ENSP00000339191	signal transducer and activator of transcription 1, 91kDa	caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway	0.740
STAT1	DMBT1	ENSP00000354394	ENSP00000357905	signal transducer and activator of transcription 1, 91kDa	deleted in malignant brain tumors 1	0.800

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