node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AURKA | AURKB | ENSP00000216911 | ENSP00000463999 | aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] | aurora kinase B | 0.928 |
AURKA | GABPB2 | ENSP00000216911 | ENSP00000357914 | aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] | GA binding protein transcription factor, beta subunit 2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity) | 0.685 |
AURKB | AURKA | ENSP00000463999 | ENSP00000216911 | aurora kinase B | aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] | 0.928 |
AURKB | AURKC | ENSP00000463999 | ENSP00000302898 | aurora kinase B | aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...] | 0.955 |
AURKB | GABPB2 | ENSP00000463999 | ENSP00000357914 | aurora kinase B | GA binding protein transcription factor, beta subunit 2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity) | 0.687 |
AURKC | AURKB | ENSP00000302898 | ENSP00000463999 | aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...] | aurora kinase B | 0.955 |
AURKC | GABPB2 | ENSP00000302898 | ENSP00000357914 | aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...] | GA binding protein transcription factor, beta subunit 2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity) | 0.685 |
BAI2 | GABPB2 | ENSP00000362762 | ENSP00000357914 | brain-specific angiogenesis inhibitor 2; Might be involved in angiogenesis inhibition | GA binding protein transcription factor, beta subunit 2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity) | 0.576 |
CCDC101 | CSRP2BP | ENSP00000316114 | ENSP00000278816 | coiled-coil domain containing 101; Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated ’Lys-4’ of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation | CSRP2 binding protein; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle | 0.959 |
CCDC101 | GABPB2 | ENSP00000316114 | ENSP00000357914 | coiled-coil domain containing 101; Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated ’Lys-4’ of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation | GA binding protein transcription factor, beta subunit 2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity) | 0.485 |
CCDC101 | MOCS2 | ENSP00000316114 | ENSP00000380157 | coiled-coil domain containing 101; Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated ’Lys-4’ of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation | molybdenum cofactor synthesis 2; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group | 0.836 |
CSRP2BP | CCDC101 | ENSP00000278816 | ENSP00000316114 | CSRP2 binding protein; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle | coiled-coil domain containing 101; Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated ’Lys-4’ of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation | 0.959 |
CSRP2BP | GABPB2 | ENSP00000278816 | ENSP00000357914 | CSRP2 binding protein; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle | GA binding protein transcription factor, beta subunit 2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity) | 0.485 |
CSRP2BP | MOCS2 | ENSP00000278816 | ENSP00000380157 | CSRP2 binding protein; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle | molybdenum cofactor synthesis 2; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group | 0.797 |
GABPB2 | AURKA | ENSP00000357914 | ENSP00000216911 | GA binding protein transcription factor, beta subunit 2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity) | aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] | 0.685 |
GABPB2 | AURKB | ENSP00000357914 | ENSP00000463999 | GA binding protein transcription factor, beta subunit 2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity) | aurora kinase B | 0.687 |
GABPB2 | AURKC | ENSP00000357914 | ENSP00000302898 | GA binding protein transcription factor, beta subunit 2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity) | aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...] | 0.685 |
GABPB2 | BAI2 | ENSP00000357914 | ENSP00000362762 | GA binding protein transcription factor, beta subunit 2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity) | brain-specific angiogenesis inhibitor 2; Might be involved in angiogenesis inhibition | 0.576 |
GABPB2 | CCDC101 | ENSP00000357914 | ENSP00000316114 | GA binding protein transcription factor, beta subunit 2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity) | coiled-coil domain containing 101; Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated ’Lys-4’ of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation | 0.485 |
GABPB2 | CSRP2BP | ENSP00000357914 | ENSP00000278816 | GA binding protein transcription factor, beta subunit 2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity) | CSRP2 binding protein; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle | 0.485 |