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LMO1 LMO1 RYBP RYBP CCDC101 CCDC101 BAI2 BAI2 MOCS2 MOCS2 GABPB2 GABPB2 CSRP2BP CSRP2BP HIF1AN HIF1AN AURKA AURKA AURKC AURKC AURKB AURKB
"GABPB2" - GA binding protein transcription factor, beta subunit 2 in Homo sapiens
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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GABPB2GA binding protein transcription factor, beta subunit 2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats) (By similarity) (448 aa)    
Predicted Functional Partners:
AURKB
aurora kinase B (344 aa)
            score_image   0.687
AURKC
aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...] (309 aa)
            score_image   0.685
AURKA
aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] (403 aa)
            score_image   0.685
LMO1
LIM domain only 1 (rhombotin 1); May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors (156 aa)
        score_image   score_image   0.684
MOCS2
molybdenum cofactor synthesis 2; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group (188 aa)
        score_image   score_image   0.609
BAI2
brain-specific angiogenesis inhibitor 2; Might be involved in angiogenesis inhibition (1585 aa)
        score_image       0.576
RYBP
RING1 and YY1 binding protein; Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis (317 aa)
        score_image       0.569
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor; Hydroxylates HIF-1 alpha at ’Asp-803’ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also [...] (349 aa)
        score_image       0.564
CCDC101
coiled-coil domain containing 101; Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated ’Lys-4’ of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation (293 aa)
            score_image   0.485
CSRP2BP
CSRP2 binding protein; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle (782 aa)
        score_image   score_image   0.485
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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