node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CS | DDO | ENSP00000342056 | ENSP00000357920 | citrate synthase | D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate | 0.817 |
CS | GOT1 | ENSP00000342056 | ENSP00000359539 | citrate synthase | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.890 |
CS | GOT2 | ENSP00000342056 | ENSP00000245206 | citrate synthase | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.940 |
CS | IDH1 | ENSP00000342056 | ENSP00000260985 | citrate synthase | isocitrate dehydrogenase 1 (NADP+), soluble | 0.890 |
CS | IDH2 | ENSP00000342056 | ENSP00000331897 | citrate synthase | isocitrate dehydrogenase 2 (NADP+), mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex | 0.904 |
CS | IL4I1 | ENSP00000342056 | ENSP00000342557 | citrate synthase | interleukin 4 induced 1; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity) | 0.810 |
CS | MDH1 | ENSP00000342056 | ENSP00000438144 | citrate synthase | malate dehydrogenase 1, NAD (soluble) | 0.987 |
CS | NIT2 | ENSP00000342056 | ENSP00000377696 | citrate synthase | nitrilase family, member 2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle | 0.800 |
CS | OGDHL | ENSP00000342056 | ENSP00000363216 | citrate synthase | oxoglutarate dehydrogenase-like | 0.621 |
CS | PCK1 | ENSP00000342056 | ENSP00000319814 | citrate synthase | phosphoenolpyruvate carboxykinase 1 (soluble); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle | 0.924 |
DDO | CS | ENSP00000357920 | ENSP00000342056 | D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate | citrate synthase | 0.817 |
DDO | GOT1 | ENSP00000357920 | ENSP00000359539 | D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.900 |
DDO | GOT2 | ENSP00000357920 | ENSP00000245206 | D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.900 |
DDO | IDH1 | ENSP00000357920 | ENSP00000260985 | D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate | isocitrate dehydrogenase 1 (NADP+), soluble | 0.814 |
DDO | IDH2 | ENSP00000357920 | ENSP00000331897 | D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate | isocitrate dehydrogenase 2 (NADP+), mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex | 0.803 |
DDO | IL4I1 | ENSP00000357920 | ENSP00000342557 | D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate | interleukin 4 induced 1; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity) | 0.906 |
DDO | MDH1 | ENSP00000357920 | ENSP00000438144 | D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate | malate dehydrogenase 1, NAD (soluble) | 0.800 |
DDO | NIT2 | ENSP00000357920 | ENSP00000377696 | D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate | nitrilase family, member 2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle | 0.905 |
DDO | OGDHL | ENSP00000357920 | ENSP00000363216 | D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate | oxoglutarate dehydrogenase-like | 0.817 |
DDO | PCK1 | ENSP00000357920 | ENSP00000319814 | D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate | phosphoenolpyruvate carboxykinase 1 (soluble); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle | 0.804 |