node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HNF4A | HNF4G | ENSP00000312987 | ENSP00000379701 | hepatocyte nuclear factor 4, alpha | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | 0.901 |
HNF4A | NR1D1 | ENSP00000312987 | ENSP00000246672 | hepatocyte nuclear factor 4, alpha | nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine | 0.910 |
HNF4A | NR2C1 | ENSP00000312987 | ENSP00000333275 | hepatocyte nuclear factor 4, alpha | nuclear receptor subfamily 2, group C, member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5’-AGGTCA-3’ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiat [...] | 0.915 |
HNF4A | NR2C2 | ENSP00000312987 | ENSP00000320447 | hepatocyte nuclear factor 4, alpha | nuclear receptor subfamily 2, group C, member 2; Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elemen [...] | 0.962 |
HNF4A | NR2E1 | ENSP00000312987 | ENSP00000357982 | hepatocyte nuclear factor 4, alpha | nuclear receptor subfamily 2, group E, member 1; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5’-AAGGTCA-3’ in which the 5’ flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involv [...] | 0.909 |
HNF4A | NR4A1 | ENSP00000312987 | ENSP00000353427 | hepatocyte nuclear factor 4, alpha | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 | 0.914 |
HNF4A | NR4A2 | ENSP00000312987 | ENSP00000344479 | hepatocyte nuclear factor 4, alpha | nuclear receptor subfamily 4, group A, member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity) | 0.911 |
HNF4A | NR5A1 | ENSP00000312987 | ENSP00000362690 | hepatocyte nuclear factor 4, alpha | nuclear receptor subfamily 5, group A, member 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5’-YCAAGGYC-3’ and 5’-RRAGGTCA-3’ are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional a [...] | 0.910 |
HNF4A | RORB | ENSP00000312987 | ENSP00000366093 | hepatocyte nuclear factor 4, alpha | RAR-related orphan receptor B; Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5’-AGGTCA-3’ in the OPN1SW promoter (By similarity) | 0.905 |
HNF4G | HNF4A | ENSP00000379701 | ENSP00000312987 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | hepatocyte nuclear factor 4, alpha | 0.901 |
HNF4G | NR1D1 | ENSP00000379701 | ENSP00000246672 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine | 0.908 |
HNF4G | NR2C1 | ENSP00000379701 | ENSP00000333275 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | nuclear receptor subfamily 2, group C, member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5’-AGGTCA-3’ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiat [...] | 0.917 |
HNF4G | NR2C2 | ENSP00000379701 | ENSP00000320447 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | nuclear receptor subfamily 2, group C, member 2; Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elemen [...] | 0.913 |
HNF4G | NR2E1 | ENSP00000379701 | ENSP00000357982 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | nuclear receptor subfamily 2, group E, member 1; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5’-AAGGTCA-3’ in which the 5’ flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involv [...] | 0.911 |
HNF4G | NR4A1 | ENSP00000379701 | ENSP00000353427 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 | 0.905 |
HNF4G | NR4A2 | ENSP00000379701 | ENSP00000344479 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | nuclear receptor subfamily 4, group A, member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity) | 0.906 |
HNF4G | NR5A1 | ENSP00000379701 | ENSP00000362690 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | nuclear receptor subfamily 5, group A, member 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5’-YCAAGGYC-3’ and 5’-RRAGGTCA-3’ are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional a [...] | 0.910 |
HNF4G | RORB | ENSP00000379701 | ENSP00000366093 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | RAR-related orphan receptor B; Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5’-AGGTCA-3’ in the OPN1SW promoter (By similarity) | 0.911 |
NR1D1 | HNF4A | ENSP00000246672 | ENSP00000312987 | nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine | hepatocyte nuclear factor 4, alpha | 0.910 |
NR1D1 | HNF4G | ENSP00000246672 | ENSP00000379701 | nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | 0.908 |