ECM1 protein (Homo sapiens) - STRING network view

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Score

ECM1

extracellular matrix protein 1 (567 aa)

Predicted Functional Partners:

EFEMP1

0.923

TFAP2C

0.814

TFAP2A

0.813

FREM1

0.754

FRAS1

0.752

FBLN1

0.740

HSPG2

0.738

IL2RB

0.582

TPRN

0.579

IL1RN

0.517

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ECM1	EFEMP1	ENSP00000358045	ENSP00000347596	extracellular matrix protein 1	EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth	0.923
ECM1	FBLN1	ENSP00000358045	ENSP00000331544	extracellular matrix protein 1	fibulin 1	0.740
ECM1	FRAS1	ENSP00000358045	ENSP00000264895	extracellular matrix protein 1	Fraser syndrome 1	0.752
ECM1	FREM1	ENSP00000358045	ENSP00000370262	extracellular matrix protein 1	FRAS1 related extracellular matrix 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development (By similarity)	0.754
ECM1	HSPG2	ENSP00000358045	ENSP00000363827	extracellular matrix protein 1	heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development	0.738
ECM1	IL1RN	ENSP00000358045	ENSP00000259206	extracellular matrix protein 1	interleukin 1 receptor antagonist; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure	0.517
ECM1	IL2RB	ENSP00000358045	ENSP00000216223	extracellular matrix protein 1	interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2	0.582
ECM1	TFAP2A	ENSP00000358045	ENSP00000368924	extracellular matrix protein 1	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis [...]	0.813
ECM1	TFAP2C	ENSP00000358045	ENSP00000201031	extracellular matrix protein 1	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma); Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC	0.814
ECM1	TPRN	ENSP00000358045	ENSP00000387100	extracellular matrix protein 1	taperin	0.579
EFEMP1	ECM1	ENSP00000347596	ENSP00000358045	EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth	extracellular matrix protein 1	0.923
EFEMP1	FBLN1	ENSP00000347596	ENSP00000331544	EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth	fibulin 1	0.914
FBLN1	ECM1	ENSP00000331544	ENSP00000358045	fibulin 1	extracellular matrix protein 1	0.740
FBLN1	EFEMP1	ENSP00000331544	ENSP00000347596	fibulin 1	EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth	0.914
FBLN1	HSPG2	ENSP00000331544	ENSP00000363827	fibulin 1	heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development	0.954
FRAS1	ECM1	ENSP00000264895	ENSP00000358045	Fraser syndrome 1	extracellular matrix protein 1	0.752
FREM1	ECM1	ENSP00000370262	ENSP00000358045	FRAS1 related extracellular matrix 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development (By similarity)	extracellular matrix protein 1	0.754
HSPG2	ECM1	ENSP00000363827	ENSP00000358045	heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development	extracellular matrix protein 1	0.738
HSPG2	FBLN1	ENSP00000363827	ENSP00000331544	heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development	fibulin 1	0.954
IL1RN	ECM1	ENSP00000259206	ENSP00000358045	interleukin 1 receptor antagonist; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure	extracellular matrix protein 1	0.517

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