node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FARS2 | FARSB | ENSP00000274680 | ENSP00000281828 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | phenylalanyl-tRNA synthetase, beta subunit | 0.988 |
FARS2 | GARS | ENSP00000274680 | ENSP00000373918 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs | 0.822 |
FARS2 | HARS | ENSP00000274680 | ENSP00000425634 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | histidyl-tRNA synthetase | 0.853 |
FARS2 | IARS | ENSP00000274680 | ENSP00000364794 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | isoleucyl-tRNA synthetase | 0.954 |
FARS2 | IARS2 | ENSP00000274680 | ENSP00000303279 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | isoleucyl-tRNA synthetase 2, mitochondrial | 0.970 |
FARS2 | LARS | ENSP00000274680 | ENSP00000377954 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | leucyl-tRNA synthetase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction- the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs | 0.921 |
FARS2 | NARS | ENSP00000274680 | ENSP00000256854 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | asparaginyl-tRNA synthetase | 0.855 |
FARS2 | SARS | ENSP00000274680 | ENSP00000234677 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) | 0.876 |
FARS2 | TARS2 | ENSP00000274680 | ENSP00000358060 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | threonyl-tRNA synthetase 2, mitochondrial (putative) | 0.973 |
FARS2 | YARS | ENSP00000274680 | ENSP00000362576 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.995 |
FARSB | FARS2 | ENSP00000281828 | ENSP00000274680 | phenylalanyl-tRNA synthetase, beta subunit | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | 0.988 |
FARSB | GARS | ENSP00000281828 | ENSP00000373918 | phenylalanyl-tRNA synthetase, beta subunit | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs | 0.812 |
FARSB | HARS | ENSP00000281828 | ENSP00000425634 | phenylalanyl-tRNA synthetase, beta subunit | histidyl-tRNA synthetase | 0.637 |
FARSB | IARS | ENSP00000281828 | ENSP00000364794 | phenylalanyl-tRNA synthetase, beta subunit | isoleucyl-tRNA synthetase | 0.988 |
FARSB | IARS2 | ENSP00000281828 | ENSP00000303279 | phenylalanyl-tRNA synthetase, beta subunit | isoleucyl-tRNA synthetase 2, mitochondrial | 0.879 |
FARSB | LARS | ENSP00000281828 | ENSP00000377954 | phenylalanyl-tRNA synthetase, beta subunit | leucyl-tRNA synthetase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction- the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs | 0.814 |
FARSB | NARS | ENSP00000281828 | ENSP00000256854 | phenylalanyl-tRNA synthetase, beta subunit | asparaginyl-tRNA synthetase | 0.803 |
FARSB | SARS | ENSP00000281828 | ENSP00000234677 | phenylalanyl-tRNA synthetase, beta subunit | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) | 0.772 |
FARSB | TARS2 | ENSP00000281828 | ENSP00000358060 | phenylalanyl-tRNA synthetase, beta subunit | threonyl-tRNA synthetase 2, mitochondrial (putative) | 0.927 |
FARSB | YARS | ENSP00000281828 | ENSP00000362576 | phenylalanyl-tRNA synthetase, beta subunit | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.930 |