AIM1 protein (Homo sapiens) - STRING network view

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Score

AIM1

absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton (1723 aa)

Predicted Functional Partners:

AURKB

0.961

INCENP

0.935

BIRC5

0.914

CDCA8

0.804

ST5

0.738

SDCBP

0.700

MMP11

0.658

SEPT1

0.628

MARVELD1

0.625

ST13

0.620

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM1	AURKB	ENSP00000358062	ENSP00000463999	absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton	aurora kinase B	0.961
AIM1	BIRC5	ENSP00000358062	ENSP00000301633	absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton	baculoviral IAP repeat containing 5	0.914
AIM1	CDCA8	ENSP00000358062	ENSP00000316121	absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton	cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment	0.804
AIM1	INCENP	ENSP00000358062	ENSP00000378295	absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton	inner centromere protein antigens 135/155kDa; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1	0.935
AIM1	MARVELD1	ENSP00000358062	ENSP00000441365	absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton	MARVEL domain containing 1; Microtubule-associated protein that exhibits cell cycle- dependent localization and can inhibit cell proliferation and migration (By similarity)	0.625
AIM1	MMP11	ENSP00000358062	ENSP00000215743	absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton	matrix metallopeptidase 11 (stromelysin 3); May play an important role in the progression of epithelial malignancies	0.658
AIM1	SDCBP	ENSP00000358062	ENSP00000260130	absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton	syndecan binding protein (syntenin); Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway	0.700
AIM1	SEPT1	ENSP00000358062	ENSP00000460441	absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton	septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	0.628
AIM1	ST13	ENSP00000358062	ENSP00000216218	absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein); One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity)	0.620
AIM1	ST5	ENSP00000358062	ENSP00000319678	absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton	suppression of tumorigenicity 5	0.738
AURKB	AIM1	ENSP00000463999	ENSP00000358062	aurora kinase B	absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton	0.961
AURKB	BIRC5	ENSP00000463999	ENSP00000301633	aurora kinase B	baculoviral IAP repeat containing 5	0.999
AURKB	CDCA8	ENSP00000463999	ENSP00000316121	aurora kinase B	cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment	0.999
AURKB	INCENP	ENSP00000463999	ENSP00000378295	aurora kinase B	inner centromere protein antigens 135/155kDa; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1	0.999
AURKB	SEPT1	ENSP00000463999	ENSP00000460441	aurora kinase B	septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	0.997
BIRC5	AIM1	ENSP00000301633	ENSP00000358062	baculoviral IAP repeat containing 5	absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton	0.914
BIRC5	AURKB	ENSP00000301633	ENSP00000463999	baculoviral IAP repeat containing 5	aurora kinase B	0.999
BIRC5	CDCA8	ENSP00000301633	ENSP00000316121	baculoviral IAP repeat containing 5	cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment	0.999
BIRC5	INCENP	ENSP00000301633	ENSP00000378295	baculoviral IAP repeat containing 5	inner centromere protein antigens 135/155kDa; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1	0.999
CDCA8	AIM1	ENSP00000316121	ENSP00000358062	cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment	absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton	0.804

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