node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAG1 | BAG2 | ENSP00000420514 | ENSP00000359727 | BCL2-associated athanogene | BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release | 0.885 |
BAG1 | BAG3 | ENSP00000420514 | ENSP00000358081 | BCL2-associated athanogene | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | 0.902 |
BAG1 | BCL2 | ENSP00000420514 | ENSP00000329623 | BCL2-associated athanogene | B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) | 0.990 |
BAG1 | HSP90AA1 | ENSP00000420514 | ENSP00000335153 | BCL2-associated athanogene | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.634 |
BAG1 | HSPA4 | ENSP00000420514 | ENSP00000302961 | BCL2-associated athanogene | heat shock 70kDa protein 4 | 0.999 |
BAG1 | HSPA8 | ENSP00000420514 | ENSP00000227378 | BCL2-associated athanogene | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | 0.999 |
BAG1 | MCL1 | ENSP00000420514 | ENSP00000358022 | BCL2-associated athanogene | myeloid cell leukemia sequence 1 (BCL2-related) | 0.472 |
BAG1 | UBC | ENSP00000420514 | ENSP00000344818 | BCL2-associated athanogene | ubiquitin C | 0.900 |
BAG2 | BAG1 | ENSP00000359727 | ENSP00000420514 | BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release | BCL2-associated athanogene | 0.885 |
BAG2 | BAG3 | ENSP00000359727 | ENSP00000358081 | BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | 0.827 |
BAG2 | HSP90AA1 | ENSP00000359727 | ENSP00000335153 | BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.681 |
BAG2 | HSPA4 | ENSP00000359727 | ENSP00000302961 | BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release | heat shock 70kDa protein 4 | 0.786 |
BAG2 | HSPA8 | ENSP00000359727 | ENSP00000227378 | BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | 0.998 |
BAG2 | UBC | ENSP00000359727 | ENSP00000344818 | BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release | ubiquitin C | 0.973 |
BAG3 | BAG1 | ENSP00000358081 | ENSP00000420514 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | BCL2-associated athanogene | 0.902 |
BAG3 | BAG2 | ENSP00000358081 | ENSP00000359727 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release | 0.827 |
BAG3 | BCL2 | ENSP00000358081 | ENSP00000329623 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) | 0.900 |
BAG3 | HSF1 | ENSP00000358081 | ENSP00000431512 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | heat shock transcription factor 1; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked | 0.966 |
BAG3 | HSP90AA1 | ENSP00000358081 | ENSP00000335153 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.946 |
BAG3 | HSPA4 | ENSP00000358081 | ENSP00000302961 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | heat shock 70kDa protein 4 | 0.997 |