node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACMSD | CA14 | ENSP00000348459 | ENSP00000358107 | aminocarboxymuconate semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway | carbonic anhydrase XIV | 0.542 |
CA14 | ACMSD | ENSP00000358107 | ENSP00000348459 | carbonic anhydrase XIV | aminocarboxymuconate semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway | 0.542 |
CA14 | CCT8 | ENSP00000358107 | ENSP00000286788 | carbonic anhydrase XIV | chaperonin containing TCP1, subunit 8 (theta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin | 0.413 |
CA14 | CIB2 | ENSP00000358107 | ENSP00000258930 | carbonic anhydrase XIV | calcium and integrin binding family member 2; Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process (By similarity) | 0.517 |
CA14 | COPB2 | ENSP00000358107 | ENSP00000329419 | carbonic anhydrase XIV | coatomer protein complex, subunit beta 2 (beta prime); The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding [...] | 0.512 |
CA14 | DONSON | ENSP00000358107 | ENSP00000307143 | carbonic anhydrase XIV | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | 0.440 |
CA14 | PKD2L1 | ENSP00000358107 | ENSP00000325296 | carbonic anhydrase XIV | polycystic kidney disease 2-like 1; May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling | 0.609 |
CCT8 | CA14 | ENSP00000286788 | ENSP00000358107 | chaperonin containing TCP1, subunit 8 (theta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin | carbonic anhydrase XIV | 0.413 |
CIB2 | CA14 | ENSP00000258930 | ENSP00000358107 | calcium and integrin binding family member 2; Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process (By similarity) | carbonic anhydrase XIV | 0.517 |
CIB2 | COPB2 | ENSP00000258930 | ENSP00000329419 | calcium and integrin binding family member 2; Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process (By similarity) | coatomer protein complex, subunit beta 2 (beta prime); The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding [...] | 0.597 |
CIB2 | DONSON | ENSP00000258930 | ENSP00000307143 | calcium and integrin binding family member 2; Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process (By similarity) | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | 0.581 |
COPB2 | CA14 | ENSP00000329419 | ENSP00000358107 | coatomer protein complex, subunit beta 2 (beta prime); The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding [...] | carbonic anhydrase XIV | 0.512 |
COPB2 | CIB2 | ENSP00000329419 | ENSP00000258930 | coatomer protein complex, subunit beta 2 (beta prime); The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding [...] | calcium and integrin binding family member 2; Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process (By similarity) | 0.597 |
COPB2 | DONSON | ENSP00000329419 | ENSP00000307143 | coatomer protein complex, subunit beta 2 (beta prime); The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding [...] | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | 0.563 |
DONSON | CA14 | ENSP00000307143 | ENSP00000358107 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | carbonic anhydrase XIV | 0.440 |
DONSON | CIB2 | ENSP00000307143 | ENSP00000258930 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | calcium and integrin binding family member 2; Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process (By similarity) | 0.581 |
DONSON | COPB2 | ENSP00000307143 | ENSP00000329419 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | coatomer protein complex, subunit beta 2 (beta prime); The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding [...] | 0.563 |
PKD2L1 | CA14 | ENSP00000325296 | ENSP00000358107 | polycystic kidney disease 2-like 1; May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling | carbonic anhydrase XIV | 0.609 |