node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000254995 | RAB5A | ENSP00000457522 | ENSP00000273047 | STX16-NPEPL1 readthrough (non-protein coding) | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | 0.430 |
ENSG00000254995 | STX6 | ENSP00000457522 | ENSP00000258301 | STX16-NPEPL1 readthrough (non-protein coding) | syntaxin 6; Involved in intracellular vesicle trafficking | 0.988 |
ENSG00000254995 | STX7 | ENSP00000457522 | ENSP00000356918 | STX16-NPEPL1 readthrough (non-protein coding) | syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes | 0.495 |
ENSG00000254995 | VPS16 | ENSP00000457522 | ENSP00000369810 | STX16-NPEPL1 readthrough (non-protein coding) | vacuolar protein sorting 16 homolog (S. cerevisiae); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes | 0.635 |
ENSG00000254995 | VPS18 | ENSP00000457522 | ENSP00000220509 | STX16-NPEPL1 readthrough (non-protein coding) | vacuolar protein sorting 18 homolog (S. cerevisiae); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes | 0.590 |
ENSG00000254995 | VPS45 | ENSP00000457522 | ENSP00000358126 | STX16-NPEPL1 readthrough (non-protein coding) | vacuolar protein sorting 45 homolog (S. cerevisiae); May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network | 0.926 |
ENSG00000254995 | VTI1B | ENSP00000457522 | ENSP00000450731 | STX16-NPEPL1 readthrough (non-protein coding) | vesicle transport through interaction with t-SNAREs homolog 1B (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence | 0.976 |
ENSG00000254995 | ZFYVE20 | ENSP00000457522 | ENSP00000253699 | STX16-NPEPL1 readthrough (non-protein coding) | zinc finger, FYVE domain containing 20; Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) | 0.499 |
RAB5A | ENSG00000254995 | ENSP00000273047 | ENSP00000457522 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | STX16-NPEPL1 readthrough (non-protein coding) | 0.430 |
RAB5A | STX16 | ENSP00000273047 | ENSP00000360183 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | syntaxin 16 | 0.583 |
RAB5A | STX6 | ENSP00000273047 | ENSP00000258301 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | syntaxin 6; Involved in intracellular vesicle trafficking | 0.695 |
RAB5A | STX7 | ENSP00000273047 | ENSP00000356918 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes | 0.659 |
RAB5A | UBC | ENSP00000273047 | ENSP00000344818 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | ubiquitin C | 0.951 |
RAB5A | VPS16 | ENSP00000273047 | ENSP00000369810 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | vacuolar protein sorting 16 homolog (S. cerevisiae); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes | 0.736 |
RAB5A | VPS18 | ENSP00000273047 | ENSP00000220509 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | vacuolar protein sorting 18 homolog (S. cerevisiae); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes | 0.617 |
RAB5A | VPS45 | ENSP00000273047 | ENSP00000358126 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | vacuolar protein sorting 45 homolog (S. cerevisiae); May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network | 0.967 |
RAB5A | VTI1B | ENSP00000273047 | ENSP00000450731 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | vesicle transport through interaction with t-SNAREs homolog 1B (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence | 0.632 |
RAB5A | ZFYVE20 | ENSP00000273047 | ENSP00000253699 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | zinc finger, FYVE domain containing 20; Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) | 0.999 |
STX16 | RAB5A | ENSP00000360183 | ENSP00000273047 | syntaxin 16 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | 0.583 |
STX16 | STX6 | ENSP00000360183 | ENSP00000258301 | syntaxin 16 | syntaxin 6; Involved in intracellular vesicle trafficking | 0.999 |