UFL1 protein (Homo sapiens) - STRING network view

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UFL1

UFM1-specific ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3 (794 aa)

Predicted Functional Partners:

DDRGK1

0.990

CDK5RAP3

0.984

UFC1

0.953

MMP9

0.916

UFSP2

0.850

UBA5

0.795

UFSP1

0.770

UBC

0.667

URM1

0.660

UFM1

0.660

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK5RAP3	DDRGK1	ENSP00000344683	ENSP00000346483	CDK5 regulatory subunit associated protein 3; Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity)	DDRGK domain containing 1	0.981
CDK5RAP3	MMP9	ENSP00000344683	ENSP00000361405	CDK5 regulatory subunit associated protein 3; Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity)	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-\|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide	0.581
CDK5RAP3	UBC	ENSP00000344683	ENSP00000344818	CDK5 regulatory subunit associated protein 3; Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity)	ubiquitin C	0.994
CDK5RAP3	UFC1	ENSP00000344683	ENSP00000356982	CDK5 regulatory subunit associated protein 3; Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity)	ubiquitin-fold modifier conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage	0.763
CDK5RAP3	UFL1	ENSP00000344683	ENSP00000358283	CDK5 regulatory subunit associated protein 3; Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity)	UFM1-specific ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3	0.984
CDK5RAP3	UFM1	ENSP00000344683	ENSP00000239878	CDK5 regulatory subunit associated protein 3; Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity)	ubiquitin-fold modifier 1; Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1	0.743
CDK5RAP3	UFSP2	ENSP00000344683	ENSP00000264689	CDK5 regulatory subunit associated protein 3; Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity)	UFM1-specific peptidase 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity)	0.423
DDRGK1	CDK5RAP3	ENSP00000346483	ENSP00000344683	DDRGK domain containing 1	CDK5 regulatory subunit associated protein 3; Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity)	0.981
DDRGK1	UBA5	ENSP00000346483	ENSP00000348565	DDRGK domain containing 1	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	0.729
DDRGK1	UBC	ENSP00000346483	ENSP00000344818	DDRGK domain containing 1	ubiquitin C	0.806
DDRGK1	UFC1	ENSP00000346483	ENSP00000356982	DDRGK domain containing 1	ubiquitin-fold modifier conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage	0.722
DDRGK1	UFL1	ENSP00000346483	ENSP00000358283	DDRGK domain containing 1	UFM1-specific ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3	0.990
DDRGK1	UFM1	ENSP00000346483	ENSP00000239878	DDRGK domain containing 1	ubiquitin-fold modifier 1; Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1	0.952
DDRGK1	UFSP1	ENSP00000346483	ENSP00000373413	DDRGK domain containing 1	UFM1-specific peptidase 1 (non-functional)	0.775
DDRGK1	UFSP2	ENSP00000346483	ENSP00000264689	DDRGK domain containing 1	UFM1-specific peptidase 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity)	0.856
DDRGK1	URM1	ENSP00000346483	ENSP00000412922	DDRGK domain containing 1	ubiquitin related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however unclear in vivo	0.684
MMP9	CDK5RAP3	ENSP00000361405	ENSP00000344683	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-\|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide	CDK5 regulatory subunit associated protein 3; Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity)	0.581
MMP9	UFL1	ENSP00000361405	ENSP00000358283	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-\|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide	UFM1-specific ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3	0.916
UBA5	DDRGK1	ENSP00000348565	ENSP00000346483	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	DDRGK domain containing 1	0.729
UBA5	UBC	ENSP00000348565	ENSP00000344818	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	ubiquitin C	0.740

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