Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | C10orf118 | chromosome 10 open reading frame 118 (898 aa) | ||||||||||||
Predicted Functional Partners:
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 | UBC | ubiquitin C (685 aa) |
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0.620 | ||||||||||
 | RECK | reversion-inducing-cysteine-rich protein with kazal motifs; Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression (971 aa) |
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0.616 | ||||||||||
 | HEATR7B2 | HEAT repeat family member 7B2 (1585 aa) |
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0.587 | ||||||||||
 | CNTLN | centlein, centrosomal protein (1406 aa) |
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0.507 | ||||||||||
 | SMAD3 | SMAD family member 3 (425 aa) |
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0.495 | ||||||||||
 | IFT43 | intraflagellar transport 43 homolog (Chlamydomonas); Component of IFT complex A (IFT-A) involved in retrograde ciliary transport along microtubules from the ciliary tip to the base (213 aa) |
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0.483 | ||||||||||
 | HEATR7B1 | HEAT repeat containing 7B1 (1676 aa) |
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0.481 | ||||||||||
 | HEATR7A | HEAT repeat containing 7A (1641 aa) |
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0.481 | ||||||||||
 | SGSM1 | small G protein signaling modulator 1 (1148 aa) |
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0.461 | ||||||||||
 | SGSM2 | small G protein signaling modulator 2 (1051 aa) |
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0.461 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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