node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASP4 | SCAF11 | ENSP00000388566 | ENSP00000358374 | caspase 4, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1 | SR-related CTD-associated factor 11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly | 0.755 |
LSM14A | SCAF11 | ENSP00000413964 | ENSP00000358374 | LSM14A, SCD6 homolog A (S. cerevisiae); Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs | SR-related CTD-associated factor 11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly | 0.613 |
SCAF11 | CASP4 | ENSP00000358374 | ENSP00000388566 | SR-related CTD-associated factor 11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly | caspase 4, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1 | 0.755 |
SCAF11 | LSM14A | ENSP00000358374 | ENSP00000413964 | SR-related CTD-associated factor 11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly | LSM14A, SCD6 homolog A (S. cerevisiae); Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs | 0.613 |
SCAF11 | SNRNP70 | ENSP00000358374 | ENSP00000472998 | SR-related CTD-associated factor 11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly | small nuclear ribonucleoprotein 70kDa (U1) | 0.772 |
SCAF11 | SRPK1 | ENSP00000358374 | ENSP00000362931 | SR-related CTD-associated factor 11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | 0.589 |
SCAF11 | SRSF1 | ENSP00000358374 | ENSP00000258962 | SR-related CTD-associated factor 11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly | serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5’-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5’-RGAAGAAC-3’ (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5’- CGAGGCG-3’ motif in vitro. Three copies of the octame [...] | 0.644 |
SCAF11 | SRSF2 | ENSP00000358374 | ENSP00000353089 | SR-related CTD-associated factor 11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly | serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5’- and 3’-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5’-AGSAGAGTA-3’ (S=C or G) or [...] | 0.782 |
SCAF11 | SRSF3 | ENSP00000358374 | ENSP00000362820 | SR-related CTD-associated factor 11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly | serine/arginine-rich splicing factor 3; May be involved in RNA processing in relation with cellular proliferation and/or maturation | 0.648 |
SCAF11 | SRSF4 | ENSP00000358374 | ENSP00000362900 | SR-related CTD-associated factor 11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly | serine/arginine-rich splicing factor 4; Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 | 0.635 |
SCAF11 | U2AF2 | ENSP00000358374 | ENSP00000307863 | SR-related CTD-associated factor 11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly | U2 small nuclear RNA auxiliary factor 2; Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10 | 0.974 |
SCAF11 | UBC | ENSP00000358374 | ENSP00000344818 | SR-related CTD-associated factor 11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly | ubiquitin C | 0.721 |
SNRNP70 | SCAF11 | ENSP00000472998 | ENSP00000358374 | small nuclear ribonucleoprotein 70kDa (U1) | SR-related CTD-associated factor 11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly | 0.772 |
SNRNP70 | SRPK1 | ENSP00000472998 | ENSP00000362931 | small nuclear ribonucleoprotein 70kDa (U1) | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | 0.968 |
SNRNP70 | SRSF1 | ENSP00000472998 | ENSP00000258962 | small nuclear ribonucleoprotein 70kDa (U1) | serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5’-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5’-RGAAGAAC-3’ (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5’- CGAGGCG-3’ motif in vitro. Three copies of the octame [...] | 0.999 |
SNRNP70 | SRSF2 | ENSP00000472998 | ENSP00000353089 | small nuclear ribonucleoprotein 70kDa (U1) | serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5’- and 3’-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5’-AGSAGAGTA-3’ (S=C or G) or [...] | 0.998 |
SNRNP70 | SRSF3 | ENSP00000472998 | ENSP00000362820 | small nuclear ribonucleoprotein 70kDa (U1) | serine/arginine-rich splicing factor 3; May be involved in RNA processing in relation with cellular proliferation and/or maturation | 0.994 |
SNRNP70 | SRSF4 | ENSP00000472998 | ENSP00000362900 | small nuclear ribonucleoprotein 70kDa (U1) | serine/arginine-rich splicing factor 4; Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 | 0.994 |
SNRNP70 | U2AF2 | ENSP00000472998 | ENSP00000307863 | small nuclear ribonucleoprotein 70kDa (U1) | U2 small nuclear RNA auxiliary factor 2; Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10 | 0.995 |
SNRNP70 | UBC | ENSP00000472998 | ENSP00000344818 | small nuclear ribonucleoprotein 70kDa (U1) | ubiquitin C | 0.894 |