Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
KIAA0664 KIAA0664 NLE1 NLE1 TEX10 TEX10 MDN1 MDN1 UBC UBC GNL2 GNL2 GTPBP4 GTPBP4 SDAD1 SDAD1 POLR1A POLR1A PES1 PES1 MKI67IP MKI67IP
MDN1, midasin homolog in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MDN1MDN1, midasin homolog (yeast); Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By similarity) (5596 aa)    
Predicted Functional Partners:
SDAD1
SDA1 domain containing 1; Required for 60S pre-ribosomal subunits export to the cytoplasm (By similarity) (687 aa)
      score_image score_image   score_image   0.978
TEX10
testis expressed 10; Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (929 aa)
      score_image score_image   score_image   0.977
NLE1
notchless homolog 1 (Drosophila) (485 aa)
      score_image score_image   score_image   0.970
GNL2
guanine nucleotide binding protein-like 2 (nucleolar); GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity) (731 aa)
      score_image score_image   score_image   0.966
PES1
pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (588 aa)
      score_image score_image   score_image   0.936
UBC
ubiquitin C (685 aa)
        score_image       0.935
GTPBP4
GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) (634 aa)
      score_image score_image   score_image   0.916
MKI67IP
MKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa)
        score_image       0.889
KIAA0664
KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) (1309 aa)
      score_image score_image       0.881
POLR1A
polymerase (RNA) I polypeptide A, 194kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of [...] (1720 aa)
      score_image         0.861
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (46%)