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CYP11A1 CYP11A1 HSD17B3 HSD17B3 HSD17B6 HSD17B6 CYP11B2 CYP11B2 SRD5A1 SRD5A1 CYP17A1 CYP17A1 HSD3B2 HSD3B2 CYP19A1 CYP19A1 CYP7B1 CYP7B1 CYP7A1 CYP7A1 CYP11B1 CYP11B1
"HSD3B2" - hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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white nodes:
second shell of interactors
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from curated databases
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Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining
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protein homology
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Score
HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids (372 aa)    
Predicted Functional Partners:
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty (508 aa)
         score_image score_image score_image   0.990
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3; Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH (310 aa)
           score_image score_image   0.979
HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...] (317 aa)
           score_image score_image   0.975
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis (504 aa)
       score_image score_image score_image score_image   0.973
CYP19A1
cytochrome P450, family 19, subfamily A, polypeptide 1; Catalyzes the formation of aromatic C18 estrogens from C19 androgens (503 aa)
         score_image score_image score_image   0.972
CYP11B1
cytochrome P450, family 11, subfamily B, polypeptide 1; Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB (503 aa)
         score_image score_image score_image   0.970
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1; Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone (521 aa)
         score_image score_image score_image   0.968
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2; Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone (503 aa)
         score_image score_image score_image   0.967
SRD5A1
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (259 aa)
           score_image score_image   0.962
CYP7B1
cytochrome P450, family 7, subfamily B, polypeptide 1 (506 aa)
       score_image score_image score_image score_image   0.958
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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