node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD2 | CD247 | ENSP00000358490 | ENSP00000354782 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | 0.972 |
CD2 | CD2AP | ENSP00000358490 | ENSP00000352264 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | 0.987 |
CD2 | CD2BP2 | ENSP00000358490 | ENSP00000304903 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly | 0.999 |
CD2 | CD4 | ENSP00000358490 | ENSP00000011653 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | 0.956 |
CD2 | CD48 | ENSP00000358490 | ENSP00000357025 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | CD48 molecule; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation | 0.966 |
CD2 | CD5 | ENSP00000358490 | ENSP00000342681 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | CD5 molecule; May act as a receptor in regulating T-cell proliferation | 0.956 |
CD2 | CD58 | ENSP00000358490 | ENSP00000358501 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | CD58 molecule; Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells | 0.999 |
CD2 | LCK | ENSP00000358490 | ENSP00000337825 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | lymphocyte-specific protein tyrosine kinase | 0.979 |
CD2 | SH3KBP1 | ENSP00000358490 | ENSP00000380921 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by intera [...] | 0.964 |
CD2 | SYK | ENSP00000358490 | ENSP00000364898 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.983 |
CD247 | CD2 | ENSP00000354782 | ENSP00000358490 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | 0.972 |
CD247 | CD4 | ENSP00000354782 | ENSP00000011653 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | 0.949 |
CD247 | CD48 | ENSP00000354782 | ENSP00000357025 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD48 molecule; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation | 0.627 |
CD247 | CD5 | ENSP00000354782 | ENSP00000342681 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD5 molecule; May act as a receptor in regulating T-cell proliferation | 0.676 |
CD247 | LCK | ENSP00000354782 | ENSP00000337825 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | lymphocyte-specific protein tyrosine kinase | 0.999 |
CD247 | SYK | ENSP00000354782 | ENSP00000364898 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.944 |
CD2AP | CD2 | ENSP00000352264 | ENSP00000358490 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | 0.987 |
CD2AP | CD58 | ENSP00000352264 | ENSP00000358501 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | CD58 molecule; Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells | 0.832 |
CD2AP | SH3KBP1 | ENSP00000352264 | ENSP00000380921 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by intera [...] | 0.834 |
CD2BP2 | CD2 | ENSP00000304903 | ENSP00000358490 | CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | 0.999 |