Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | FUNDC2 | FUN14 domain containing 2 (189 aa) | ||||||||||||
Predicted Functional Partners:
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 | VBP1 | von Hippel-Lindau binding protein 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (197 aa) |
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0.578 | ||||||||||
 | RAB39B | RAB39B, member RAS oncogene family; May be involved in vesicular trafficking. Plays a role in synapse formation (By similarity) (213 aa) |
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0.567 | ||||||||||
 | H2AFB3 | H2A histone family, member B3; Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and a [...] (115 aa) |
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0.566 | ||||||||||
 | HSFX2 | heat shock transcription factor family, X linked 2 (423 aa) |
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0.538 | ||||||||||
 | HSFX1 | heat shock transcription factor family, X linked 1 (423 aa) |
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0.538 | ||||||||||
 | TMEM185A | transmembrane protein 185A (350 aa) |
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0.533 | ||||||||||
 | ZNF687 | zinc finger protein 687; May be involved in transcriptional regulation (1237 aa) |
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0.515 | ||||||||||
 | COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle); This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport (79 aa) |
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0.487 | ||||||||||
 | C6orf203 | chromosome 6 open reading frame 203 (245 aa) |
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0.479 | ||||||||||
 | TMLHE | trimethyllysine hydroxylase, epsilon; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) (421 aa) |
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0.457 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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