CNR1 protein (Homo sapiens) - STRING network view

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CNR1

cannabinoid receptor 1 (brain) (472 aa)

Predicted Functional Partners:

VR1

0.992

TRPV1

0.992

GPR55

0.967

DRD2

0.958

GNAI3

0.956

GNAI1

0.956

NPY

0.956

POMC

0.954

GPR18

0.951

SST

0.951

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNR1	DRD2	ENSP00000358511	ENSP00000354859	cannabinoid receptor 1 (brain)	dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)	0.958
CNR1	GNAI1	ENSP00000358511	ENSP00000343027	cannabinoid receptor 1 (brain)	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	0.956
CNR1	GNAI3	ENSP00000358511	ENSP00000358867	cannabinoid receptor 1 (brain)	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division	0.956
CNR1	GPR18	ENSP00000358511	ENSP00000343428	cannabinoid receptor 1 (brain)	G protein-coupled receptor 18; Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system	0.951
CNR1	GPR55	ENSP00000358511	ENSP00000375893	cannabinoid receptor 1 (brain)	G protein-coupled receptor 55; May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L- alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function	0.967
CNR1	NPY	ENSP00000358511	ENSP00000242152	cannabinoid receptor 1 (brain)	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	0.956
CNR1	POMC	ENSP00000358511	ENSP00000264708	cannabinoid receptor 1 (brain)	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.954
CNR1	SST	ENSP00000358511	ENSP00000287641	cannabinoid receptor 1 (brain)	somatostatin; Somatostatin inhibits the release of somatotropin	0.951
CNR1	TRPV1	ENSP00000358511	ENSP00000382659	cannabinoid receptor 1 (brain)	transient receptor potential cation channel, subfamily V, member 1; Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Trigger [...]	0.992
CNR1	VR1	ENSP00000358511	ENSP00000459962	cannabinoid receptor 1 (brain)	transient receptor potential cation channel subfamily V member 1 ; Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers [...]	0.992
DRD2	CNR1	ENSP00000354859	ENSP00000358511	dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)	cannabinoid receptor 1 (brain)	0.958
DRD2	GNAI1	ENSP00000354859	ENSP00000343027	dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	0.909
DRD2	GNAI3	ENSP00000354859	ENSP00000358867	dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division	0.959
DRD2	GPR18	ENSP00000354859	ENSP00000343428	dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)	G protein-coupled receptor 18; Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system	0.901
DRD2	GPR55	ENSP00000354859	ENSP00000375893	dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)	G protein-coupled receptor 55; May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L- alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function	0.906
DRD2	NPY	ENSP00000354859	ENSP00000242152	dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	0.937
DRD2	POMC	ENSP00000354859	ENSP00000264708	dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.943
DRD2	SST	ENSP00000354859	ENSP00000287641	dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)	somatostatin; Somatostatin inhibits the release of somatotropin	0.948
GNAI1	CNR1	ENSP00000343027	ENSP00000358511	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	cannabinoid receptor 1 (brain)	0.956
GNAI1	DRD2	ENSP00000343027	ENSP00000354859	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)	0.909

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