node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MOB4 | MST4 | ENSP00000315702 | ENSP00000377867 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | 0.999 |
MOB4 | PDCD10 | ENSP00000315702 | ENSP00000376506 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | programmed cell death 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity) | 0.999 |
MOB4 | SIKE1 | ENSP00000315702 | ENSP00000358541 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways | 0.999 |
MOB4 | SLMAP | ENSP00000315702 | ENSP00000295951 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | sarcolemma associated protein | 0.999 |
MOB4 | STK24 | ENSP00000315702 | ENSP00000365730 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | serine/threonine kinase 24; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on ’Thr-442’ and stimulates [...] | 0.999 |
MOB4 | STRIP1 | ENSP00000315702 | ENSP00000358810 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | striatin interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape | 0.999 |
MOB4 | STRIP2 | ENSP00000315702 | ENSP00000249344 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | striatin interacting protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape | 0.999 |
MOB4 | STRN | ENSP00000315702 | ENSP00000263918 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | striatin, calmodulin binding protein; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling | 0.999 |
MOB4 | STRN3 | ENSP00000315702 | ENSP00000350071 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | striatin, calmodulin binding protein 3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein | 0.999 |
MOB4 | STRN4 | ENSP00000315702 | ENSP00000375777 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | striatin, calmodulin binding protein 4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein | 0.999 |
MST4 | MOB4 | ENSP00000377867 | ENSP00000315702 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | 0.999 |
MST4 | PDCD10 | ENSP00000377867 | ENSP00000376506 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | programmed cell death 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity) | 0.999 |
MST4 | SIKE1 | ENSP00000377867 | ENSP00000358541 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways | 0.999 |
MST4 | SLMAP | ENSP00000377867 | ENSP00000295951 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | sarcolemma associated protein | 0.999 |
MST4 | STK24 | ENSP00000377867 | ENSP00000365730 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | serine/threonine kinase 24; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on ’Thr-442’ and stimulates [...] | 0.999 |
MST4 | STRIP1 | ENSP00000377867 | ENSP00000358810 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | striatin interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape | 0.999 |
MST4 | STRIP2 | ENSP00000377867 | ENSP00000249344 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | striatin interacting protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape | 0.999 |
MST4 | STRN | ENSP00000377867 | ENSP00000263918 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | striatin, calmodulin binding protein; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling | 0.999 |
MST4 | STRN3 | ENSP00000377867 | ENSP00000350071 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | striatin, calmodulin binding protein 3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein | 0.999 |
MST4 | STRN4 | ENSP00000377867 | ENSP00000375777 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | striatin, calmodulin binding protein 4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein | 0.999 |