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STRINGSTRING
SLMAP SLMAP STRIP1 STRIP1 PDCD10 PDCD10 MST4 MST4 STK24 STK24 STRN4 STRN4 STRIP2 STRIP2 STRN STRN MOB4 MOB4 STRN3 STRN3 SIKE1 SIKE1
"SIKE1" - suppressor of IKBKE 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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textmining
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co-expression
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protein homology
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SIKE1suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (211 aa)    
Predicted Functional Partners:
STRN
striatin, calmodulin binding protein; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling (780 aa)
        score_image   score_image   0.999
STRN4
striatin, calmodulin binding protein 4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (760 aa)
        score_image   score_image   0.999
STRIP2
striatin interacting protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (834 aa)
        score_image   score_image   0.999
STRIP1
striatin interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (837 aa)
        score_image   score_image   0.999
STRN3
striatin, calmodulin binding protein 3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (797 aa)
        score_image   score_image   0.999
MST4
Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis (416 aa)
        score_image   score_image   0.999
SLMAP
sarcolemma associated protein (811 aa)
        score_image   score_image   0.999
STK24
serine/threonine kinase 24; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on ’Thr-442’ and stimulates [...] (443 aa)
        score_image   score_image   0.999
MOB4
MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) (225 aa)
        score_image   score_image   0.999
PDCD10
programmed cell death 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity) (212 aa)
        score_image   score_image   0.999
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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