node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCAS2 | BUD31 | ENSP00000358554 | ENSP00000222969 | breast carcinoma amplified sequence 2; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | BUD31 homolog (S. cerevisiae) | 0.886 |
BCAS2 | CDC40 | ENSP00000358554 | ENSP00000304370 | breast carcinoma amplified sequence 2; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | 0.908 |
BCAS2 | CDC5L | ENSP00000358554 | ENSP00000360532 | breast carcinoma amplified sequence 2; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.999 |
BCAS2 | CTNNBL1 | ENSP00000358554 | ENSP00000355050 | breast carcinoma amplified sequence 2; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | catenin, beta like 1 | 0.999 |
BCAS2 | HSPA8 | ENSP00000358554 | ENSP00000227378 | breast carcinoma amplified sequence 2; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | 0.999 |
BCAS2 | MAGOH | ENSP00000358554 | ENSP00000360525 | breast carcinoma amplified sequence 2; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | mago-nashi homolog, proliferation-associated (Drosophila); Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mR [...] | 0.996 |
BCAS2 | MFAP1 | ENSP00000358554 | ENSP00000267812 | breast carcinoma amplified sequence 2; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | microfibrillar-associated protein 1; Component of the elastin-associated microfibrils | 0.946 |
BCAS2 | PLRG1 | ENSP00000358554 | ENSP00000424417 | breast carcinoma amplified sequence 2; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | pleiotropic regulator 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity) | 0.999 |
BCAS2 | PRPF19 | ENSP00000358554 | ENSP00000227524 | breast carcinoma amplified sequence 2; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.999 |
BCAS2 | SF3A2 | ENSP00000358554 | ENSP00000221494 | breast carcinoma amplified sequence 2; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | splicing factor 3a, subunit 2, 66kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex | 0.895 |
BUD31 | BCAS2 | ENSP00000222969 | ENSP00000358554 | BUD31 homolog (S. cerevisiae) | breast carcinoma amplified sequence 2; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | 0.886 |
BUD31 | CDC40 | ENSP00000222969 | ENSP00000304370 | BUD31 homolog (S. cerevisiae) | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | 0.959 |
BUD31 | CDC5L | ENSP00000222969 | ENSP00000360532 | BUD31 homolog (S. cerevisiae) | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.978 |
BUD31 | CTNNBL1 | ENSP00000222969 | ENSP00000355050 | BUD31 homolog (S. cerevisiae) | catenin, beta like 1 | 0.965 |
BUD31 | PLRG1 | ENSP00000222969 | ENSP00000424417 | BUD31 homolog (S. cerevisiae) | pleiotropic regulator 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity) | 0.974 |
BUD31 | PRPF19 | ENSP00000222969 | ENSP00000227524 | BUD31 homolog (S. cerevisiae) | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.980 |
BUD31 | SF3A2 | ENSP00000222969 | ENSP00000221494 | BUD31 homolog (S. cerevisiae) | splicing factor 3a, subunit 2, 66kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex | 0.890 |
CDC40 | BCAS2 | ENSP00000304370 | ENSP00000358554 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | breast carcinoma amplified sequence 2; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | 0.908 |
CDC40 | BUD31 | ENSP00000304370 | ENSP00000222969 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | BUD31 homolog (S. cerevisiae) | 0.959 |
CDC40 | CDC5L | ENSP00000304370 | ENSP00000360532 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.983 |