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STRINGSTRING
MRPL43 MRPL43 RBM33 RBM33 SF1 SF1 NGF NGF NGFR NGFR SORCS3 SORCS3 PICK1 PICK1 PSRC1 PSRC1 TACC2 TACC2 CELSR2 CELSR2 COG2 COG2
"SORCS3" - sortilin-related VPS10 domain containing receptor 3 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
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gene co-occurrence
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textmining
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co-expression
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protein homology
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Score
SORCS3sortilin-related VPS10 domain containing receptor 3 (1222 aa)    
Predicted Functional Partners:
NGF
nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival (241 aa)
        score_image score_image score_image   0.962
NGFR
nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells (427 aa)
          score_image score_image   0.916
PICK1
protein interacting with PRKCA 1; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel (415 aa)
            score_image   0.787
MRPL43
mitochondrial ribosomal protein L43 (235 aa)
            score_image   0.758
PSRC1
proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (333 aa)
            score_image   0.681
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation (2923 aa)
            score_image   0.680
RBM33
RNA binding motif protein 33 (1170 aa)
        score_image       0.644
SF1
splicing factor 1 (673 aa)
        score_image       0.644
TACC2
transforming, acidic coiled-coil containing protein 2 (2948 aa)
            score_image   0.586
COG2
component of oligomeric golgi complex 2; Required for normal Golgi morphology and function (738 aa)
            score_image   0.493
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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