node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CELSR2 | COG2 | ENSP00000271332 | ENSP00000355629 | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function | 0.512 |
CELSR2 | PSRC1 | ENSP00000271332 | ENSP00000358919 | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation | proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression | 0.813 |
CELSR2 | SORCS3 | ENSP00000271332 | ENSP00000358715 | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation | sortilin-related VPS10 domain containing receptor 3 | 0.680 |
COG2 | CELSR2 | ENSP00000355629 | ENSP00000271332 | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation | 0.512 |
COG2 | PSRC1 | ENSP00000355629 | ENSP00000358919 | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function | proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression | 0.515 |
COG2 | SORCS3 | ENSP00000355629 | ENSP00000358715 | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function | sortilin-related VPS10 domain containing receptor 3 | 0.493 |
MRPL43 | SORCS3 | ENSP00000339844 | ENSP00000358715 | mitochondrial ribosomal protein L43 | sortilin-related VPS10 domain containing receptor 3 | 0.758 |
NGF | NGFR | ENSP00000358525 | ENSP00000172229 | nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | 0.999 |
NGF | SORCS3 | ENSP00000358525 | ENSP00000358715 | nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival | sortilin-related VPS10 domain containing receptor 3 | 0.962 |
NGFR | NGF | ENSP00000172229 | ENSP00000358525 | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival | 0.999 |
NGFR | SORCS3 | ENSP00000172229 | ENSP00000358715 | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | sortilin-related VPS10 domain containing receptor 3 | 0.916 |
PICK1 | SORCS3 | ENSP00000349465 | ENSP00000358715 | protein interacting with PRKCA 1; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel | sortilin-related VPS10 domain containing receptor 3 | 0.787 |
PSRC1 | CELSR2 | ENSP00000358919 | ENSP00000271332 | proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation | 0.813 |
PSRC1 | COG2 | ENSP00000358919 | ENSP00000355629 | proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function | 0.515 |
PSRC1 | SORCS3 | ENSP00000358919 | ENSP00000358715 | proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression | sortilin-related VPS10 domain containing receptor 3 | 0.681 |
RBM33 | SORCS3 | ENSP00000384160 | ENSP00000358715 | RNA binding motif protein 33 | sortilin-related VPS10 domain containing receptor 3 | 0.644 |
SF1 | SORCS3 | ENSP00000366604 | ENSP00000358715 | splicing factor 1 | sortilin-related VPS10 domain containing receptor 3 | 0.644 |
SORCS3 | CELSR2 | ENSP00000358715 | ENSP00000271332 | sortilin-related VPS10 domain containing receptor 3 | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation | 0.680 |
SORCS3 | COG2 | ENSP00000358715 | ENSP00000355629 | sortilin-related VPS10 domain containing receptor 3 | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function | 0.493 |
SORCS3 | MRPL43 | ENSP00000358715 | ENSP00000339844 | sortilin-related VPS10 domain containing receptor 3 | mitochondrial ribosomal protein L43 | 0.758 |