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LDHC LDHC MDH1 MDH1 MDH2 MDH2 PC PC FH FH EHHADH EHHADH PKM PKM ME1 ME1 LDHB LDHB LDHAL6A LDHAL6A LDHAL6B LDHAL6B
"ME1" - malic enzyme 1, NADP(+)-dependent, cytosolic in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
ME1malic enzyme 1, NADP(+)-dependent, cytosolic (572 aa)    
Predicted Functional Partners:
MDH1
malate dehydrogenase 1, NAD (soluble) (352 aa)
score_image     score_image score_image score_image score_image   0.986
PKM
pyruvate kinase, muscle (531 aa)
      score_image   score_image score_image   0.977
LDHC
lactate dehydrogenase C; Possible role in sperm motility (332 aa)
score_image     score_image score_image score_image score_image   0.974
LDHB
lactate dehydrogenase B (334 aa)
score_image     score_image score_image score_image score_image   0.974
FH
fumarate hydratase; Also acts as a tumor suppressor (510 aa)
score_image score_image   score_image   score_image score_image   0.972
PC
pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (1178 aa)
      score_image score_image score_image score_image   0.971
MDH2
malate dehydrogenase 2, NAD (mitochondrial) (338 aa)
score_image     score_image score_image score_image score_image   0.963
LDHAL6B
lactate dehydrogenase A-like 6B (381 aa)
score_image     score_image score_image score_image score_image   0.953
LDHAL6A
lactate dehydrogenase A-like 6A; Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed (332 aa)
score_image     score_image score_image score_image score_image   0.953
EHHADH
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (723 aa)
          score_image score_image   0.930
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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