SFR1 protein (Homo sapiens) - STRING network view

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[Homology]

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SFR1

SWI5-dependent recombination repair 1; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (245 aa)

Predicted Functional Partners:

SWI5

0.998

RAD51C

0.949

RAD51D

0.905

RAD51B

0.905

XRCC3

0.905

XRCC2

0.900

C5orf50

0.700

RAD51

0.663

GUK1

0.613

WDR96

0.587

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C5orf50	SFR1	ENSP00000331214	ENSP00000358742	chromosome 5 open reading frame 50	SWI5-dependent recombination repair 1; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination	0.700
C5orf50	WDR96	ENSP00000331214	ENSP00000349568	chromosome 5 open reading frame 50	WD repeat domain 96	0.720
GUK1	RAD51	ENSP00000355689	ENSP00000372088	guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	0.449
GUK1	SFR1	ENSP00000355689	ENSP00000358742	guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP	SWI5-dependent recombination repair 1; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination	0.613
RAD51	GUK1	ENSP00000372088	ENSP00000355689	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP	0.449
RAD51	RAD51B	ENSP00000372088	ENSP00000419471	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	RAD51 homolog B (S. cerevisiae)	0.700
RAD51	RAD51C	ENSP00000372088	ENSP00000336701	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	RAD51 homolog C (S. cerevisiae); Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in t [...]	0.998
RAD51	RAD51D	ENSP00000372088	ENSP00000466399	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	RAD51 homolog D (S. cerevisiae)	0.682
RAD51	SFR1	ENSP00000372088	ENSP00000358742	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	SWI5-dependent recombination repair 1; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination	0.663
RAD51	SWI5	ENSP00000372088	ENSP00000316609	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	SWI5 recombination repair homolog (yeast); Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination	0.656
RAD51	XRCC2	ENSP00000372088	ENSP00000352271	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 2; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA	0.719
RAD51	XRCC3	ENSP00000372088	ENSP00000343392	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C	0.991
RAD51B	RAD51	ENSP00000419471	ENSP00000372088	RAD51 homolog B (S. cerevisiae)	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	0.700
RAD51B	RAD51C	ENSP00000419471	ENSP00000336701	RAD51 homolog B (S. cerevisiae)	RAD51 homolog C (S. cerevisiae); Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in t [...]	0.999
RAD51B	RAD51D	ENSP00000419471	ENSP00000466399	RAD51 homolog B (S. cerevisiae)	RAD51 homolog D (S. cerevisiae)	0.997
RAD51B	SFR1	ENSP00000419471	ENSP00000358742	RAD51 homolog B (S. cerevisiae)	SWI5-dependent recombination repair 1; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination	0.905
RAD51B	SWI5	ENSP00000419471	ENSP00000316609	RAD51 homolog B (S. cerevisiae)	SWI5 recombination repair homolog (yeast); Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination	0.905
RAD51B	XRCC2	ENSP00000419471	ENSP00000352271	RAD51 homolog B (S. cerevisiae)	X-ray repair complementing defective repair in Chinese hamster cells 2; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA	0.987
RAD51B	XRCC3	ENSP00000419471	ENSP00000343392	RAD51 homolog B (S. cerevisiae)	X-ray repair complementing defective repair in Chinese hamster cells 3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C	0.978
RAD51C	RAD51	ENSP00000336701	ENSP00000372088	RAD51 homolog C (S. cerevisiae); Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in t [...]	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	0.998

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