node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BSG | SLC16A4 | ENSP00000333769 | ENSP00000358794 | basigin (Ok blood group); Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes (By similarity) | solute carrier family 16, member 4 (monocarboxylic acid transporter 5) | 0.972 |
CA9 | HIF1A | ENSP00000367608 | ENSP00000338018 | carbonic anhydrase IX; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...] | 0.994 |
CA9 | LDHA | ENSP00000367608 | ENSP00000445175 | carbonic anhydrase IX; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia | lactate dehydrogenase A | 0.414 |
CA9 | SLC16A4 | ENSP00000367608 | ENSP00000358794 | carbonic anhydrase IX; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia | solute carrier family 16, member 4 (monocarboxylic acid transporter 5) | 0.508 |
CA9 | SLC2A1 | ENSP00000367608 | ENSP00000416293 | carbonic anhydrase IX; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia | solute carrier family 2 (facilitated glucose transporter), member 1; Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses | 0.659 |
CA9 | SLC2A14 | ENSP00000367608 | ENSP00000379834 | carbonic anhydrase IX; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia | solute carrier family 2 (facilitated glucose transporter), member 14; Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis | 0.418 |
CA9 | SLC9A1 | ENSP00000367608 | ENSP00000263980 | carbonic anhydrase IX; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction | 0.457 |
CBLL1 | SLC16A4 | ENSP00000401277 | ENSP00000358794 | Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1; Promotes ubiquitination of several tyrosine- phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation (By similarity) | solute carrier family 16, member 4 (monocarboxylic acid transporter 5) | 0.847 |
CS | LDHA | ENSP00000342056 | ENSP00000445175 | citrate synthase | lactate dehydrogenase A | 0.856 |
CS | SLC16A4 | ENSP00000342056 | ENSP00000358794 | citrate synthase | solute carrier family 16, member 4 (monocarboxylic acid transporter 5) | 0.499 |
CS | SLC2A4 | ENSP00000342056 | ENSP00000320935 | citrate synthase | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | 0.658 |
HIF1A | CA9 | ENSP00000338018 | ENSP00000367608 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...] | carbonic anhydrase IX; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia | 0.994 |
HIF1A | LDHA | ENSP00000338018 | ENSP00000445175 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...] | lactate dehydrogenase A | 0.983 |
HIF1A | SLC16A4 | ENSP00000338018 | ENSP00000358794 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...] | solute carrier family 16, member 4 (monocarboxylic acid transporter 5) | 0.504 |
HIF1A | SLC2A1 | ENSP00000338018 | ENSP00000416293 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...] | solute carrier family 2 (facilitated glucose transporter), member 1; Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses | 0.998 |
HIF1A | SLC2A14 | ENSP00000338018 | ENSP00000379834 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...] | solute carrier family 2 (facilitated glucose transporter), member 14; Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis | 0.889 |
HIF1A | SLC2A4 | ENSP00000338018 | ENSP00000320935 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...] | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | 0.837 |
LDHA | CA9 | ENSP00000445175 | ENSP00000367608 | lactate dehydrogenase A | carbonic anhydrase IX; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia | 0.414 |
LDHA | CS | ENSP00000445175 | ENSP00000342056 | lactate dehydrogenase A | citrate synthase | 0.856 |
LDHA | HIF1A | ENSP00000445175 | ENSP00000338018 | lactate dehydrogenase A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...] | 0.983 |