node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALX3 | EFNB1 | ENSP00000358807 | ENSP00000204961 | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | ephrin-B1; Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity) | 0.607 |
ALX3 | FOXI1 | ENSP00000358807 | ENSP00000304286 | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | forkhead box I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity) | 0.601 |
ALX3 | ITPA | ENSP00000358807 | ENSP00000369456 | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | 0.585 |
ALX3 | MRTO4 | ENSP00000358807 | ENSP00000364320 | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) | 0.752 |
ALX3 | PDIA3 | ENSP00000358807 | ENSP00000300289 | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | protein disulfide isomerase family A, member 3 | 0.607 |
ALX3 | PJA1 | ENSP00000358807 | ENSP00000355014 | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | praja ring finger 1, E3 ubiquitin protein ligase; Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting | 0.684 |
ALX3 | RBM15 | ENSP00000358807 | ENSP00000358799 | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | RNA binding motif protein 15 | 0.606 |
ALX3 | SLC6A17 | ENSP00000358807 | ENSP00000330199 | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | solute carrier family 6, member 17; Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity) | 0.748 |
ALX3 | SRF | ENSP00000358807 | ENSP00000265354 | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.708 |
ALX3 | UBL4B | ENSP00000358807 | ENSP00000334044 | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | ubiquitin-like 4B | 0.765 |
EFNB1 | ALX3 | ENSP00000204961 | ENSP00000358807 | ephrin-B1; Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity) | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | 0.607 |
EFNB1 | PJA1 | ENSP00000204961 | ENSP00000355014 | ephrin-B1; Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity) | praja ring finger 1, E3 ubiquitin protein ligase; Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting | 0.651 |
FOXI1 | ALX3 | ENSP00000304286 | ENSP00000358807 | forkhead box I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity) | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | 0.601 |
FOXI1 | SRF | ENSP00000304286 | ENSP00000265354 | forkhead box I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity) | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.483 |
ITPA | ALX3 | ENSP00000369456 | ENSP00000358807 | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | 0.585 |
MRTO4 | ALX3 | ENSP00000364320 | ENSP00000358807 | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | 0.752 |
MRTO4 | RBM15 | ENSP00000364320 | ENSP00000358799 | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) | RNA binding motif protein 15 | 0.811 |
PDIA3 | ALX3 | ENSP00000300289 | ENSP00000358807 | protein disulfide isomerase family A, member 3 | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | 0.607 |
PJA1 | ALX3 | ENSP00000355014 | ENSP00000358807 | praja ring finger 1, E3 ubiquitin protein ligase; Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting | ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) | 0.684 |
PJA1 | EFNB1 | ENSP00000355014 | ENSP00000204961 | praja ring finger 1, E3 ubiquitin protein ligase; Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting | ephrin-B1; Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity) | 0.651 |