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RBM15 RBM15 MRTO4 MRTO4 UBL4B UBL4B ITPA ITPA SLC6A17 SLC6A17 ALX3 ALX3 PDIA3 PDIA3 FOXI1 FOXI1 PJA1 PJA1 SRF SRF EFNB1 EFNB1
"ALX3" - ALX homeobox 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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[Homology]
Score
ALX3ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) (343 aa)    
Predicted Functional Partners:
UBL4B
ubiquitin-like 4B (174 aa)
        score_image   score_image   0.765
MRTO4
mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) (239 aa)
            score_image   0.752
SLC6A17
solute carrier family 6, member 17; Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity) (727 aa)
            score_image   0.748
SRF
serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation (508 aa)
        score_image   score_image   0.708
PJA1
praja ring finger 1, E3 ubiquitin protein ligase; Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting (643 aa)
            score_image   0.684
PDIA3
protein disulfide isomerase family A, member 3 (505 aa)
            score_image   0.607
EFNB1
ephrin-B1; Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity) (346 aa)
            score_image   0.607
RBM15
RNA binding motif protein 15 (977 aa)
            score_image   0.606
FOXI1
forkhead box I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity) (378 aa)
        score_image   score_image   0.601
ITPA
inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (194 aa)
            score_image   0.585
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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