node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD18A | NEURL1B | ENSP00000382610 | ENSP00000358815 | ankyrin repeat domain 18A | neuralized homolog 1B (Drosophila); E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands | 0.660 |
DLL1 | MIB1 | ENSP00000355718 | ENSP00000261537 | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | mindbomb E3 ubiquitin protein ligase 1 | 0.986 |
DLL1 | MIB2 | ENSP00000355718 | ENSP00000426103 | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | mindbomb E3 ubiquitin protein ligase 2 | 0.631 |
DLL1 | NEURL1B | ENSP00000355718 | ENSP00000358815 | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | neuralized homolog 1B (Drosophila); E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands | 0.994 |
DLL1 | NOTCH1 | ENSP00000355718 | ENSP00000277541 | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.990 |
DLL1 | NOTCH2 | ENSP00000355718 | ENSP00000256646 | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | notch 2 | 0.911 |
DLL1 | NOTCH3 | ENSP00000355718 | ENSP00000263388 | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | 0.995 |
DLL1 | NOTCH4 | ENSP00000355718 | ENSP00000364163 | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | notch 4 | 0.969 |
DLL1 | RBPJ | ENSP00000355718 | ENSP00000345206 | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | recombination signal binding protein for immunoglobulin kappa J region; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of c [...] | 0.958 |
EPN3 | MIB1 | ENSP00000268933 | ENSP00000261537 | epsin 3 | mindbomb E3 ubiquitin protein ligase 1 | 0.485 |
EPN3 | MIB2 | ENSP00000268933 | ENSP00000426103 | epsin 3 | mindbomb E3 ubiquitin protein ligase 2 | 0.485 |
EPN3 | NEURL1B | ENSP00000268933 | ENSP00000358815 | epsin 3 | neuralized homolog 1B (Drosophila); E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands | 0.679 |
MIB1 | DLL1 | ENSP00000261537 | ENSP00000355718 | mindbomb E3 ubiquitin protein ligase 1 | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | 0.986 |
MIB1 | EPN3 | ENSP00000261537 | ENSP00000268933 | mindbomb E3 ubiquitin protein ligase 1 | epsin 3 | 0.485 |
MIB1 | MIB2 | ENSP00000261537 | ENSP00000426103 | mindbomb E3 ubiquitin protein ligase 1 | mindbomb E3 ubiquitin protein ligase 2 | 0.757 |
MIB1 | NEURL1B | ENSP00000261537 | ENSP00000358815 | mindbomb E3 ubiquitin protein ligase 1 | neuralized homolog 1B (Drosophila); E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands | 0.680 |
MIB1 | NOTCH1 | ENSP00000261537 | ENSP00000277541 | mindbomb E3 ubiquitin protein ligase 1 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.921 |
MIB1 | RBPJ | ENSP00000261537 | ENSP00000345206 | mindbomb E3 ubiquitin protein ligase 1 | recombination signal binding protein for immunoglobulin kappa J region; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of c [...] | 0.553 |
MIB2 | DLL1 | ENSP00000426103 | ENSP00000355718 | mindbomb E3 ubiquitin protein ligase 2 | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | 0.631 |
MIB2 | EPN3 | ENSP00000426103 | ENSP00000268933 | mindbomb E3 ubiquitin protein ligase 2 | epsin 3 | 0.485 |