| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP5M1 | OPN1MW2 | ENSP00000261558 | ENSP00000358945 | adaptor-related protein complex 5, mu 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-18395520, it may play a role in cell death | opsin 1 (cone pigments), medium-wave-sensitive 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.480 |
| ARL6 | BBS2 | ENSP00000337722 | ENSP00000245157 | ADP-ribosylation factor-like 6; Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization | Bardet-Biedl syndrome 2; The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of [...] | 0.898 |
| ARL6 | OPN1MW2 | ENSP00000337722 | ENSP00000358945 | ADP-ribosylation factor-like 6; Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization | opsin 1 (cone pigments), medium-wave-sensitive 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.560 |
| ARR3 | CRX | ENSP00000311538 | ENSP00000221996 | arrestin 3, retinal (X-arrestin); May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | 0.449 |
| ARR3 | GNAT1 | ENSP00000311538 | ENSP00000232461 | arrestin 3, retinal (X-arrestin); May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase | 0.634 |
| ARR3 | GNAT2 | ENSP00000311538 | ENSP00000251337 | arrestin 3, retinal (X-arrestin); May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase | 0.499 |
| ARR3 | OPN1MW2 | ENSP00000311538 | ENSP00000358945 | arrestin 3, retinal (X-arrestin); May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins | opsin 1 (cone pigments), medium-wave-sensitive 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.659 |
| ARR3 | PDE6C | ENSP00000311538 | ENSP00000360502 | arrestin 3, retinal (X-arrestin); May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins | phosphodiesterase 6C, cGMP-specific, cone, alpha prime | 0.577 |
| BBS2 | ARL6 | ENSP00000245157 | ENSP00000337722 | Bardet-Biedl syndrome 2; The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of [...] | ADP-ribosylation factor-like 6; Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization | 0.898 |
| BBS2 | OPN1MW2 | ENSP00000245157 | ENSP00000358945 | Bardet-Biedl syndrome 2; The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of [...] | opsin 1 (cone pigments), medium-wave-sensitive 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.451 |
| CRX | ARR3 | ENSP00000221996 | ENSP00000311538 | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | arrestin 3, retinal (X-arrestin); May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins | 0.449 |
| CRX | GNAT1 | ENSP00000221996 | ENSP00000232461 | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase | 0.522 |
| CRX | GNAT2 | ENSP00000221996 | ENSP00000251337 | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase | 0.595 |
| CRX | OPN1MW2 | ENSP00000221996 | ENSP00000358945 | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | opsin 1 (cone pigments), medium-wave-sensitive 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.524 |
| CRX | PDE6C | ENSP00000221996 | ENSP00000360502 | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | phosphodiesterase 6C, cGMP-specific, cone, alpha prime | 0.489 |
| GNAT1 | ARR3 | ENSP00000232461 | ENSP00000311538 | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase | arrestin 3, retinal (X-arrestin); May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins | 0.634 |
| GNAT1 | CRX | ENSP00000232461 | ENSP00000221996 | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | 0.522 |
| GNAT1 | GNAT2 | ENSP00000232461 | ENSP00000251337 | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase | 0.901 |
| GNAT1 | OPN1MW2 | ENSP00000232461 | ENSP00000358945 | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase | opsin 1 (cone pigments), medium-wave-sensitive 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.619 |
| GNAT1 | PDE6C | ENSP00000232461 | ENSP00000360502 | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase | phosphodiesterase 6C, cGMP-specific, cone, alpha prime | 0.499 |
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