node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CARD17 | OPN1LW | ENSP00000364859 | ENSP00000358967 | caspase recruitment domain family, member 17; Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.564 |
DDX43 | OPN1LW | ENSP00000359361 | ENSP00000358967 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.566 |
FTH1 | OMP | ENSP00000273550 | ENSP00000436376 | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | olfactory marker protein; May act as a modulator of the olfactory signal- transduction cascade | 0.740 |
FTH1 | OPN1LW | ENSP00000273550 | ENSP00000358967 | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.624 |
FTH1 | TICAM2 | ENSP00000273550 | ENSP00000386341 | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | toll-like receptor adaptor molecule 2; Functions in LPS-TLR4 signaling to regulate the MYD88- independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1 | 0.636 |
NCOA2 | OPN1LW | ENSP00000399968 | ENSP00000358967 | nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.569 |
NCOA2 | PIAS3 | ENSP00000399968 | ENSP00000376765 | nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues | protein inhibitor of activated STAT, 3 | 0.848 |
OMP | FTH1 | ENSP00000436376 | ENSP00000273550 | olfactory marker protein; May act as a modulator of the olfactory signal- transduction cascade | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | 0.740 |
OMP | OPN1LW | ENSP00000436376 | ENSP00000358967 | olfactory marker protein; May act as a modulator of the olfactory signal- transduction cascade | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.564 |
OMP | TICAM2 | ENSP00000436376 | ENSP00000386341 | olfactory marker protein; May act as a modulator of the olfactory signal- transduction cascade | toll-like receptor adaptor molecule 2; Functions in LPS-TLR4 signaling to regulate the MYD88- independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1 | 0.501 |
OPN1LW | CARD17 | ENSP00000358967 | ENSP00000364859 | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | caspase recruitment domain family, member 17; Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation | 0.564 |
OPN1LW | DDX43 | ENSP00000358967 | ENSP00000359361 | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 | 0.566 |
OPN1LW | FTH1 | ENSP00000358967 | ENSP00000273550 | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | 0.624 |
OPN1LW | NCOA2 | ENSP00000358967 | ENSP00000399968 | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues | 0.569 |
OPN1LW | OMP | ENSP00000358967 | ENSP00000436376 | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | olfactory marker protein; May act as a modulator of the olfactory signal- transduction cascade | 0.564 |
OPN1LW | PIAS3 | ENSP00000358967 | ENSP00000376765 | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | protein inhibitor of activated STAT, 3 | 0.582 |
OPN1LW | RANBP2 | ENSP00000358967 | ENSP00000283195 | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB | 0.603 |
OPN1LW | TEX28 | ENSP00000358967 | ENSP00000355323 | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | testis expressed 28 | 0.772 |
OPN1LW | TICAM2 | ENSP00000358967 | ENSP00000386341 | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | toll-like receptor adaptor molecule 2; Functions in LPS-TLR4 signaling to regulate the MYD88- independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1 | 0.723 |
OPN1LW | TNFRSF17 | ENSP00000358967 | ENSP00000053243 | opsin 1 (cone pigments), long-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | tumor necrosis factor receptor superfamily, member 17; Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK | 0.561 |