| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CLU | STMN3 | ENSP00000315130 | ENSP00000359070 | clusterin; Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosom [...] | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | 0.836 |
| CLU | UBC | ENSP00000315130 | ENSP00000344818 | clusterin; Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosom [...] | ubiquitin C | 0.926 |
| FBXO7 | STMN3 | ENSP00000266087 | ENSP00000359070 | F-box protein 7; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5 | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | 0.525 |
| FBXO7 | UBC | ENSP00000266087 | ENSP00000344818 | F-box protein 7; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5 | ubiquitin C | 0.853 |
| LRIT1 | STMN3 | ENSP00000361177 | ENSP00000359070 | leucine-rich repeat, immunoglobulin-like and transmembrane domains 1; Possible role in phototransduction | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | 0.548 |
| LRIT1 | TAGLN3 | ENSP00000361177 | ENSP00000273368 | leucine-rich repeat, immunoglobulin-like and transmembrane domains 1; Possible role in phototransduction | transgelin 3 | 0.623 |
| LRIT1 | ZNF496 | ENSP00000361177 | ENSP00000294753 | leucine-rich repeat, immunoglobulin-like and transmembrane domains 1; Possible role in phototransduction | zinc finger protein 496; DNA-binding transcription factor that can both act as an activator and a repressor (By similarity) | 0.734 |
| MAPK8 | STMN3 | ENSP00000353483 | ENSP00000359070 | mitogen-activated protein kinase 8; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JU [...] | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | 0.822 |
| MAPK8 | UBC | ENSP00000353483 | ENSP00000344818 | mitogen-activated protein kinase 8; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JU [...] | ubiquitin C | 0.657 |
| NKX3-1 | STMN3 | ENSP00000370253 | ENSP00000359070 | NK3 homeobox 1; Transcription factor, which binds preferentially the consensus sequence 5’-TAAGT[AG]-3’ and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | 0.529 |
| STMN3 | CLU | ENSP00000359070 | ENSP00000315130 | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | clusterin; Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosom [...] | 0.836 |
| STMN3 | FBXO7 | ENSP00000359070 | ENSP00000266087 | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | F-box protein 7; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5 | 0.525 |
| STMN3 | LRIT1 | ENSP00000359070 | ENSP00000361177 | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | leucine-rich repeat, immunoglobulin-like and transmembrane domains 1; Possible role in phototransduction | 0.548 |
| STMN3 | MAPK8 | ENSP00000359070 | ENSP00000353483 | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | mitogen-activated protein kinase 8; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JU [...] | 0.822 |
| STMN3 | NKX3-1 | ENSP00000359070 | ENSP00000370253 | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | NK3 homeobox 1; Transcription factor, which binds preferentially the consensus sequence 5’-TAAGT[AG]-3’ and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells | 0.529 |
| STMN3 | TAGLN3 | ENSP00000359070 | ENSP00000273368 | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | transgelin 3 | 0.520 |
| STMN3 | TRPC5 | ENSP00000359070 | ENSP00000262839 | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | transient receptor potential cation channel, subfamily C, member 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion | 0.589 |
| STMN3 | UBC | ENSP00000359070 | ENSP00000344818 | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | ubiquitin C | 0.721 |
| STMN3 | UBQLN1 | ENSP00000359070 | ENSP00000365576 | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | ubiquilin 1; Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation | 0.564 |
| STMN3 | ZNF496 | ENSP00000359070 | ENSP00000294753 | stathmin-like 3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity) | zinc finger protein 496; DNA-binding transcription factor that can both act as an activator and a repressor (By similarity) | 0.544 |
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