| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDKL5 | GDI1 | ENSP00000369325 | ENSP00000394071 | cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2 | GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | 0.518 |
| CDKL5 | NTNG1 | ENSP00000369325 | ENSP00000359085 | cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2 | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.680 |
| DCC | NEO1 | ENSP00000389140 | ENSP00000261908 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | neogenin 1; May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues | 0.905 |
| DCC | NTNG1 | ENSP00000389140 | ENSP00000359085 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.819 |
| DCC | UNC5C | ENSP00000389140 | ENSP00000406022 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | unc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.990 |
| FNDC1 | NTNG1 | ENSP00000297267 | ENSP00000359085 | fibronectin type III domain containing 1 | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.819 |
| FNDC1 | UNC5C | ENSP00000297267 | ENSP00000406022 | fibronectin type III domain containing 1 | unc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.578 |
| GDI1 | CDKL5 | ENSP00000394071 | ENSP00000369325 | GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2 | 0.518 |
| GDI1 | IGDCC3 | ENSP00000394071 | ENSP00000332773 | GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | immunoglobulin superfamily, DCC subclass, member 3 | 0.486 |
| GDI1 | NTNG1 | ENSP00000394071 | ENSP00000359085 | GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.667 |
| IGDCC3 | GDI1 | ENSP00000332773 | ENSP00000394071 | immunoglobulin superfamily, DCC subclass, member 3 | GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | 0.486 |
| IGDCC3 | NTNG1 | ENSP00000332773 | ENSP00000359085 | immunoglobulin superfamily, DCC subclass, member 3 | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.840 |
| IGDCC3 | UNC5C | ENSP00000332773 | ENSP00000406022 | immunoglobulin superfamily, DCC subclass, member 3 | unc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.427 |
| IGDCC4 | NTNG1 | ENSP00000319623 | ENSP00000359085 | immunoglobulin superfamily, DCC subclass, member 4 | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.819 |
| IGDCC4 | UNC5C | ENSP00000319623 | ENSP00000406022 | immunoglobulin superfamily, DCC subclass, member 4 | unc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.578 |
| LRRC4C | NTNG1 | ENSP00000278198 | ENSP00000359085 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.999 |
| NEO1 | DCC | ENSP00000261908 | ENSP00000389140 | neogenin 1; May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | 0.905 |
| NEO1 | NTNG1 | ENSP00000261908 | ENSP00000359085 | neogenin 1; May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.819 |
| NEO1 | UNC5C | ENSP00000261908 | ENSP00000406022 | neogenin 1; May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues | unc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.771 |
| NTNG1 | CDKL5 | ENSP00000359085 | ENSP00000369325 | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2 | 0.680 |
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