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COL10A1 COL10A1 BPI BPI AKAP8 AKAP8 AMY1A AMY1A AKAP1 AKAP1 GBE1 GBE1 PYGB PYGB PYGL PYGL AGL AGL LCT LCT SI SI
"AMY1A" - amylase, alpha 1A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AMY1Aamylase, alpha 1A (salivary) (511 aa)    
Predicted Functional Partners:
GBE1
glucan (1,4-alpha-), branching enzyme 1; Required for sufficient glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule and, consequently, in reducing the osmotic pressure within cells (702 aa)
score_image         score_image score_image   0.960
PYGL
phosphorylase, glycogen, liver; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) (847 aa)
score_image     score_image score_image score_image score_image   0.954
PYGB
phosphorylase, glycogen; brain; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) (843 aa)
score_image     score_image score_image score_image score_image   0.953
SI
sucrase-isomaltase (alpha-glucosidase); Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides (1827 aa)
score_image         score_image score_image   0.924
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase (1532 aa)
        score_image score_image score_image   0.910
LCT
lactase; LPH splits lactose in the small intestine (1927 aa)
            score_image   0.717
BPI
bactericidal/permeability-increasing protein (487 aa)
            score_image   0.608
COL10A1
collagen, type X, alpha 1; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage (680 aa)
            score_image   0.606
AKAP1
A kinase (PRKA) anchor protein 1; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (903 aa)
        score_image       0.576
AKAP8
A kinase (PRKA) anchor protein 8; Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (692 aa)
        score_image       0.576
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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