Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | NSDHL | NAD(P) dependent steroid dehydrogenase-like (373 aa) | ||||||||||||
Predicted Functional Partners:
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 | MSMO1 | methylsterol monooxygenase 1 (293 aa) |
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0.969 | ||||||||
 | SQLE | squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway (574 aa) |
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0.967 | ||||||||
 | LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (732 aa) |
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0.945 | ||||||||
 | CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 (509 aa) |
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0.941 | ||||||||
 | SC5DL | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol (299 aa) |
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0.940 | ||||||||
 | FDFT1 | farnesyl-diphosphate farnesyltransferase 1 (417 aa) |
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0.929 | ||||||||
 | HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols (341 aa) |
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0.927 | ||||||||
 | TM7SF2 | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol (418 aa) |
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0.896 | ||||||||
 | DHCR7 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) (475 aa) |
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0.865 | ||||||||
 | C14orf1 | chromosome 14 open reading frame 1 (140 aa) |
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0.845 | ||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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