| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATOH7 | BHLHE23 | ENSP00000362777 | ENSP00000359371 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | basic helix-loop-helix family, member e23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity) | 0.559 |
| ATOH7 | DLL1 | ENSP00000362777 | ENSP00000355718 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | 0.405 |
| ATOH7 | FOXN4 | ENSP00000362777 | ENSP00000299162 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | forkhead box N4 | 0.539 |
| ATOH7 | PAX6 | ENSP00000362777 | ENSP00000368401 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | 0.923 |
| ATOH7 | POU4F2 | ENSP00000362777 | ENSP00000281321 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | POU class 4 homeobox 2; Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons | 0.973 |
| ATOH7 | TCF3 | ENSP00000362777 | ENSP00000262965 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs- 5’-CANNTG-3’. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region | 0.857 |
| ATOH7 | VSX1 | ENSP00000362777 | ENSP00000365899 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | visual system homeobox 1 | 0.508 |
| ATOH7 | VSX2 | ENSP00000362777 | ENSP00000261980 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | visual system homeobox 2; Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity) | 0.722 |
| BHLHE23 | ATOH7 | ENSP00000359371 | ENSP00000362777 | basic helix-loop-helix family, member e23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity) | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | 0.559 |
| BHLHE23 | DLL1 | ENSP00000359371 | ENSP00000355718 | basic helix-loop-helix family, member e23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity) | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | 0.539 |
| BHLHE23 | FOXN4 | ENSP00000359371 | ENSP00000299162 | basic helix-loop-helix family, member e23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity) | forkhead box N4 | 0.510 |
| BHLHE23 | IRX1 | ENSP00000359371 | ENSP00000305244 | basic helix-loop-helix family, member e23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity) | iroquois homeobox 1 | 0.517 |
| BHLHE23 | IRX5 | ENSP00000359371 | ENSP00000378132 | basic helix-loop-helix family, member e23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity) | iroquois homeobox 5; Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12 | 0.561 |
| BHLHE23 | PAX6 | ENSP00000359371 | ENSP00000368401 | basic helix-loop-helix family, member e23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity) | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | 0.524 |
| BHLHE23 | POU4F2 | ENSP00000359371 | ENSP00000281321 | basic helix-loop-helix family, member e23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity) | POU class 4 homeobox 2; Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons | 0.525 |
| BHLHE23 | TCF3 | ENSP00000359371 | ENSP00000262965 | basic helix-loop-helix family, member e23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity) | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs- 5’-CANNTG-3’. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region | 0.756 |
| BHLHE23 | VSX1 | ENSP00000359371 | ENSP00000365899 | basic helix-loop-helix family, member e23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity) | visual system homeobox 1 | 0.567 |
| BHLHE23 | VSX2 | ENSP00000359371 | ENSP00000261980 | basic helix-loop-helix family, member e23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity) | visual system homeobox 2; Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity) | 0.581 |
| DLL1 | ATOH7 | ENSP00000355718 | ENSP00000362777 | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | 0.405 |
| DLL1 | BHLHE23 | ENSP00000355718 | ENSP00000359371 | delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor | basic helix-loop-helix family, member e23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity) | 0.539 |
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