node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C4orf34 | FATE1 | ENSP00000295958 | ENSP00000359375 | chromosome 4 open reading frame 34 | fetal and adult testis expressed 1 | 0.633 |
CD79A | FATE1 | ENSP00000221972 | ENSP00000359375 | CD79a molecule, immunoglobulin-associated alpha; Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases [...] | fetal and adult testis expressed 1 | 0.403 |
EMD | FATE1 | ENSP00000358857 | ENSP00000359375 | emerin; Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The [...] | fetal and adult testis expressed 1 | 0.443 |
FATE1 | C4orf34 | ENSP00000359375 | ENSP00000295958 | fetal and adult testis expressed 1 | chromosome 4 open reading frame 34 | 0.633 |
FATE1 | CD79A | ENSP00000359375 | ENSP00000221972 | fetal and adult testis expressed 1 | CD79a molecule, immunoglobulin-associated alpha; Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases [...] | 0.403 |
FATE1 | EMD | ENSP00000359375 | ENSP00000358857 | fetal and adult testis expressed 1 | emerin; Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The [...] | 0.443 |
FATE1 | MARCH2 | ENSP00000359375 | ENSP00000215555 | fetal and adult testis expressed 1 | membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6 | 0.526 |
FATE1 | NPC1 | ENSP00000359375 | ENSP00000269228 | fetal and adult testis expressed 1 | Niemann-Pick disease, type C1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | 0.568 |
FATE1 | NRG4 | ENSP00000359375 | ENSP00000378367 | fetal and adult testis expressed 1 | neuregulin 4; Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity) | 0.478 |
FATE1 | PNMA6A | ENSP00000359375 | ENSP00000405718 | fetal and adult testis expressed 1 | paraneoplastic Ma antigen family member 6A | 0.406 |
FATE1 | SCAP | ENSP00000359375 | ENSP00000265565 | fetal and adult testis expressed 1 | SREBF chaperone; Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the [...] | 0.459 |
FATE1 | SYNGR2 | ENSP00000359375 | ENSP00000225777 | fetal and adult testis expressed 1 | synaptogyrin 2 | 0.633 |
FATE1 | YIPF2 | ENSP00000359375 | ENSP00000253031 | fetal and adult testis expressed 1 | Yip1 domain family, member 2 | 0.633 |
MARCH2 | FATE1 | ENSP00000215555 | ENSP00000359375 | membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6 | fetal and adult testis expressed 1 | 0.526 |
NPC1 | FATE1 | ENSP00000269228 | ENSP00000359375 | Niemann-Pick disease, type C1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | fetal and adult testis expressed 1 | 0.568 |
NRG4 | FATE1 | ENSP00000378367 | ENSP00000359375 | neuregulin 4; Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity) | fetal and adult testis expressed 1 | 0.478 |
PNMA6A | FATE1 | ENSP00000405718 | ENSP00000359375 | paraneoplastic Ma antigen family member 6A | fetal and adult testis expressed 1 | 0.406 |
SCAP | FATE1 | ENSP00000265565 | ENSP00000359375 | SREBF chaperone; Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the [...] | fetal and adult testis expressed 1 | 0.459 |
SYNGR2 | FATE1 | ENSP00000225777 | ENSP00000359375 | synaptogyrin 2 | fetal and adult testis expressed 1 | 0.633 |
YIPF2 | FATE1 | ENSP00000253031 | ENSP00000359375 | Yip1 domain family, member 2 | fetal and adult testis expressed 1 | 0.633 |