splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes: protein of unknown 3D structure
large nodes: some 3D structure is known or predicted
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KIAA1107
KIAA1107 (1354 aa)
Predicted Functional Partners:
ARMC3
armadillo repeat containing 3 (872 aa)
0.503
DZIP1
DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ (867 aa)
0.480
TTLL4
tubulin tyrosine ligase-like family, member 4; Polyglutamylase which preferentially modifies beta- tubulin and nucleosome assembly proteins NAP1 and NAP2. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity) (1199 aa)
0.418
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606 Other names: H. sapiens, Homo, Homo sapiens, human, man
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
ARMC3
KIAA1107
ENSP00000298032
ENSP00000359404
armadillo repeat containing 3
KIAA1107
0.503
DZIP1
KIAA1107
ENSP00000257312
ENSP00000359404
DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ
KIAA1107
0.480
KIAA1107
ARMC3
ENSP00000359404
ENSP00000298032
KIAA1107
armadillo repeat containing 3
0.503
KIAA1107
DZIP1
ENSP00000359404
ENSP00000257312
KIAA1107
DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ
0.480
KIAA1107
TTLL4
ENSP00000359404
ENSP00000258398
KIAA1107
tubulin tyrosine ligase-like family, member 4; Polyglutamylase which preferentially modifies beta- tubulin and nucleosome assembly proteins NAP1 and NAP2. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity)
0.418
TTLL4
KIAA1107
ENSP00000258398
ENSP00000359404
tubulin tyrosine ligase-like family, member 4; Polyglutamylase which preferentially modifies beta- tubulin and nucleosome assembly proteins NAP1 and NAP2. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity)
Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Neighborhood
Groups of genes that are frequently observed in each other's genomic neighborhood.
Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Fusion
Genes that are sometimes fused into single open reading frames.
Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
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Network Stats
Network Stats analysis is still ongoing, please wait ...
Functional enrichments in your networkNote: some enrichments may be expected here (why?)
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: