GBP6 protein (Homo sapiens) - STRING network view

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GBP6

guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity) (633 aa)

Predicted Functional Partners:

NCF2

0.678

SCMH1

0.598

ACTR2

0.533

FBXO18

0.531

ARV1

0.514

C19orf18

0.513

SCML2

0.509

ATP8A1

0.495

STAT1

0.456

SKP1

0.439

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTR2	FBXO18	ENSP00000367220	ENSP00000369335	ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament	F-box protein, helicase, 18	0.535
ACTR2	GBP6	ENSP00000367220	ENSP00000359485	ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	0.533
ARV1	GBP6	ENSP00000312458	ENSP00000359485	ARV1 homolog (S. cerevisiae)	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	0.514
ATP8A1	GBP6	ENSP00000371084	ENSP00000359485	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	0.495
ATP8A1	SCMH1	ENSP00000371084	ENSP00000318094	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles	sex comb on midleg homolog 1 (Drosophila); Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes (By similarity)	0.484
C19orf18	GBP6	ENSP00000321519	ENSP00000359485	chromosome 19 open reading frame 18	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	0.513
FBXO18	ACTR2	ENSP00000369335	ENSP00000367220	F-box protein, helicase, 18	ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament	0.535
FBXO18	GBP6	ENSP00000369335	ENSP00000359485	F-box protein, helicase, 18	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	0.531
FBXO18	SKP1	ENSP00000369335	ENSP00000231487	F-box protein, helicase, 18	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...]	0.998
GBP6	ACTR2	ENSP00000359485	ENSP00000367220	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament	0.533
GBP6	ARV1	ENSP00000359485	ENSP00000312458	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	ARV1 homolog (S. cerevisiae)	0.514
GBP6	ATP8A1	ENSP00000359485	ENSP00000371084	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles	0.495
GBP6	C19orf18	ENSP00000359485	ENSP00000321519	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	chromosome 19 open reading frame 18	0.513
GBP6	FBXO18	ENSP00000359485	ENSP00000369335	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	F-box protein, helicase, 18	0.531
GBP6	NCF2	ENSP00000359485	ENSP00000356505	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	neutrophil cytosolic factor 2	0.678
GBP6	SCMH1	ENSP00000359485	ENSP00000318094	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	sex comb on midleg homolog 1 (Drosophila); Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes (By similarity)	0.598
GBP6	SCML2	ENSP00000359485	ENSP00000251900	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	sex comb on midleg-like 2 (Drosophila); Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity)	0.509
GBP6	SKP1	ENSP00000359485	ENSP00000231487	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...]	0.439
GBP6	STAT1	ENSP00000359485	ENSP00000354394	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	signal transducer and activator of transcription 1, 91kDa	0.456
NCF2	GBP6	ENSP00000356505	ENSP00000359485	neutrophil cytosolic factor 2	guanylate binding protein family, member 6; Binds GTP, GDP and GMP (By similarity)	0.678

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