CUTC protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CUTC

cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit (273 aa)

Predicted Functional Partners:

CUTA

0.808

UBC

0.721

FBXL2

0.612

MRPL17

0.593

PIM2

0.551

BCL6

0.549

IRF2BP2

0.538

LIMCH1

0.538

GABPA

0.524

FBXL20

0.485

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	CUTC	ENSP00000232014	ENSP00000359507	B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	0.549
BCL6	UBC	ENSP00000232014	ENSP00000344818	B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis	ubiquitin C	0.923
CUTA	CUTC	ENSP00000363624	ENSP00000359507	cutA divalent cation tolerance homolog (E. coli)	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	0.808
CUTC	BCL6	ENSP00000359507	ENSP00000232014	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis	0.549
CUTC	CUTA	ENSP00000359507	ENSP00000363624	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	cutA divalent cation tolerance homolog (E. coli)	0.808
CUTC	FBXL2	ENSP00000359507	ENSP00000417601	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	F-box and leucine-rich repeat protein 2; Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn’t seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cy [...]	0.612
CUTC	FBXL20	ENSP00000359507	ENSP00000264658	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	F-box and leucine-rich repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity)	0.485
CUTC	GABPA	ENSP00000359507	ENSP00000346886	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	GA binding protein transcription factor, alpha subunit 60kDa; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene	0.524
CUTC	IRF2BP2	ENSP00000359507	ENSP00000355568	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	interferon regulatory factor 2 binding protein 2; Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle	0.538
CUTC	LIMCH1	ENSP00000359507	ENSP00000316891	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	LIM and calponin homology domains 1	0.538
CUTC	MRPL17	ENSP00000359507	ENSP00000288937	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	mitochondrial ribosomal protein L17	0.593
CUTC	PIM2	ENSP00000359507	ENSP00000365692	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	pim-2 oncogene; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through- the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between [...]	0.551
CUTC	UBC	ENSP00000359507	ENSP00000344818	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	ubiquitin C	0.721
FBXL2	CUTC	ENSP00000417601	ENSP00000359507	F-box and leucine-rich repeat protein 2; Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn’t seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cy [...]	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	0.612
FBXL20	CUTC	ENSP00000264658	ENSP00000359507	F-box and leucine-rich repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity)	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	0.485
FBXL20	UBC	ENSP00000264658	ENSP00000344818	F-box and leucine-rich repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity)	ubiquitin C	0.445
GABPA	CUTC	ENSP00000346886	ENSP00000359507	GA binding protein transcription factor, alpha subunit 60kDa; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	0.524
GABPA	LIMCH1	ENSP00000346886	ENSP00000316891	GA binding protein transcription factor, alpha subunit 60kDa; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene	LIM and calponin homology domains 1	0.548
GABPA	UBC	ENSP00000346886	ENSP00000344818	GA binding protein transcription factor, alpha subunit 60kDa; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene	ubiquitin C	0.805
IRF2BP2	CUTC	ENSP00000355568	ENSP00000359507	interferon regulatory factor 2 binding protein 2; Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle	cutC copper transporter homolog (E. coli); May play a role in copper homeostasis. Can bind one Cu(1+) per subunit	0.538

page 1 of 2

Experiments

Cooccurrence

Textmining

Neighborhood

Databases

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About