| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATL1 | GBP3 | ENSP00000351155 | ENSP00000359512 | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | guanylate binding protein 3 | 0.592 |
| GBP3 | ATL1 | ENSP00000359512 | ENSP00000351155 | guanylate binding protein 3 | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | 0.592 |
| GBP3 | IFIT2 | ENSP00000359512 | ENSP00000360891 | guanylate binding protein 3 | interferon-induced protein with tetratricopeptide repeats 2; IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2’-O-methylation of the 5’ cap. The ribose 2’-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2’-O-methylase for their mRNAs or by stealing host cap containing the 2’-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5’ triphosphorylat [...] | 0.439 |
| GBP3 | IFIT3 | ENSP00000359512 | ENSP00000360876 | guanylate binding protein 3 | interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1 [...] | 0.432 |
| GBP3 | MAP4K4 | ENSP00000359512 | ENSP00000314363 | guanylate binding protein 3 | mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 | 0.648 |
| GBP3 | MX2 | ENSP00000359512 | ENSP00000333657 | guanylate binding protein 3 | myxovirus (influenza virus) resistance 2 (mouse); May play a role in regulating nucleocytoplasmic transport and cell-cycle progression | 0.440 |
| GBP3 | NFATC2 | ENSP00000359512 | ENSP00000379330 | guanylate binding protein 3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.900 |
| IFIT2 | GBP3 | ENSP00000360891 | ENSP00000359512 | interferon-induced protein with tetratricopeptide repeats 2; IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2’-O-methylation of the 5’ cap. The ribose 2’-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2’-O-methylase for their mRNAs or by stealing host cap containing the 2’-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5’ triphosphorylat [...] | guanylate binding protein 3 | 0.439 |
| IFIT2 | IFIT3 | ENSP00000360891 | ENSP00000360876 | interferon-induced protein with tetratricopeptide repeats 2; IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2’-O-methylation of the 5’ cap. The ribose 2’-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2’-O-methylase for their mRNAs or by stealing host cap containing the 2’-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5’ triphosphorylat [...] | interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1 [...] | 0.981 |
| IFIT2 | MX2 | ENSP00000360891 | ENSP00000333657 | interferon-induced protein with tetratricopeptide repeats 2; IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2’-O-methylation of the 5’ cap. The ribose 2’-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2’-O-methylase for their mRNAs or by stealing host cap containing the 2’-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5’ triphosphorylat [...] | myxovirus (influenza virus) resistance 2 (mouse); May play a role in regulating nucleocytoplasmic transport and cell-cycle progression | 0.958 |
| IFIT3 | GBP3 | ENSP00000360876 | ENSP00000359512 | interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1 [...] | guanylate binding protein 3 | 0.432 |
| IFIT3 | IFIT2 | ENSP00000360876 | ENSP00000360891 | interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1 [...] | interferon-induced protein with tetratricopeptide repeats 2; IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2’-O-methylation of the 5’ cap. The ribose 2’-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2’-O-methylase for their mRNAs or by stealing host cap containing the 2’-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5’ triphosphorylat [...] | 0.981 |
| IFIT3 | MX2 | ENSP00000360876 | ENSP00000333657 | interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1 [...] | myxovirus (influenza virus) resistance 2 (mouse); May play a role in regulating nucleocytoplasmic transport and cell-cycle progression | 0.958 |
| MAP4K4 | GBP3 | ENSP00000314363 | ENSP00000359512 | mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 | guanylate binding protein 3 | 0.648 |
| MX2 | GBP3 | ENSP00000333657 | ENSP00000359512 | myxovirus (influenza virus) resistance 2 (mouse); May play a role in regulating nucleocytoplasmic transport and cell-cycle progression | guanylate binding protein 3 | 0.440 |
| MX2 | IFIT2 | ENSP00000333657 | ENSP00000360891 | myxovirus (influenza virus) resistance 2 (mouse); May play a role in regulating nucleocytoplasmic transport and cell-cycle progression | interferon-induced protein with tetratricopeptide repeats 2; IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2’-O-methylation of the 5’ cap. The ribose 2’-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2’-O-methylase for their mRNAs or by stealing host cap containing the 2’-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5’ triphosphorylat [...] | 0.958 |
| MX2 | IFIT3 | ENSP00000333657 | ENSP00000360876 | myxovirus (influenza virus) resistance 2 (mouse); May play a role in regulating nucleocytoplasmic transport and cell-cycle progression | interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1 [...] | 0.958 |
| NFATC2 | GBP3 | ENSP00000379330 | ENSP00000359512 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | guanylate binding protein 3 | 0.900 |
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