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STRINGSTRING
MDH1 MDH1 MDH2 MDH2 IDH1 IDH1 IDH2 IDH2 LDHC LDHC GOT1 GOT1 CAD CAD LDHAL6A LDHAL6A MPST MPST LDHB LDHB TST TST
"GOT1" - glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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gene co-occurrence
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textmining
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protein homology
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GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] (413 aa)    
Predicted Functional Partners:
LDHC
lactate dehydrogenase C; Possible role in sperm motility (332 aa)
      score_image   score_image score_image   0.984
LDHB
lactate dehydrogenase B (334 aa)
      score_image   score_image score_image   0.984
MDH1
malate dehydrogenase 1, NAD (soluble) (352 aa)
      score_image   score_image score_image   0.984
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (2225 aa)
      score_image score_image score_image score_image   0.977
MDH2
malate dehydrogenase 2, NAD (mitochondrial) (338 aa)
      score_image   score_image score_image   0.968
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble (414 aa)
      score_image score_image score_image score_image   0.966
MPST
mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regu [...] (317 aa)
score_image         score_image score_image   0.955
TST
thiosulfate sulfurtransferase (rhodanese); Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (297 aa)
score_image         score_image score_image   0.953
LDHAL6A
lactate dehydrogenase A-like 6A; Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed (332 aa)
      score_image   score_image score_image   0.951
IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (452 aa)
      score_image   score_image score_image   0.948
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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