node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COQ2 | ETFDH | ENSP00000310873 | ENSP00000426638 | coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB | electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone | 0.532 |
COQ2 | FDFT1 | ENSP00000310873 | ENSP00000220584 | coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB | farnesyl-diphosphate farnesyltransferase 1 | 0.457 |
COQ2 | IDI1 | ENSP00000310873 | ENSP00000370748 | coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB | isopentenyl-diphosphate delta isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.428 |
COQ2 | NDUFAF6 | ENSP00000310873 | ENSP00000379430 | coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6; Involved in the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1 | 0.492 |
COQ2 | PYROXD2 | ENSP00000310873 | ENSP00000359607 | coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB | pyridine nucleotide-disulphide oxidoreductase domain 2; Probable oxidoreductase (By similarity) | 0.463 |
COQ2 | RUSC1 | ENSP00000310873 | ENSP00000357336 | coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB | RUN and SH3 domain containing 1; Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway | 0.436 |
ETFDH | COQ2 | ENSP00000426638 | ENSP00000310873 | electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone | coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB | 0.532 |
ETFDH | F11 | ENSP00000426638 | ENSP00000384957 | electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone | coagulation factor XI; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX | 0.456 |
ETFDH | KLKB1 | ENSP00000426638 | ENSP00000264690 | electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone | kallikrein B, plasma (Fletcher factor) 1; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin | 0.456 |
ETFDH | PYROXD2 | ENSP00000426638 | ENSP00000359607 | electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone | pyridine nucleotide-disulphide oxidoreductase domain 2; Probable oxidoreductase (By similarity) | 0.562 |
F11 | ETFDH | ENSP00000384957 | ENSP00000426638 | coagulation factor XI; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX | electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone | 0.456 |
F11 | KLKB1 | ENSP00000384957 | ENSP00000264690 | coagulation factor XI; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX | kallikrein B, plasma (Fletcher factor) 1; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin | 0.906 |
F11 | PYROXD2 | ENSP00000384957 | ENSP00000359607 | coagulation factor XI; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX | pyridine nucleotide-disulphide oxidoreductase domain 2; Probable oxidoreductase (By similarity) | 0.495 |
FDFT1 | COQ2 | ENSP00000220584 | ENSP00000310873 | farnesyl-diphosphate farnesyltransferase 1 | coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB | 0.457 |
FDFT1 | IDI1 | ENSP00000220584 | ENSP00000370748 | farnesyl-diphosphate farnesyltransferase 1 | isopentenyl-diphosphate delta isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.848 |
FDFT1 | IDI2 | ENSP00000220584 | ENSP00000277517 | farnesyl-diphosphate farnesyltransferase 1 | isopentenyl-diphosphate delta isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.654 |
FDFT1 | PYROXD2 | ENSP00000220584 | ENSP00000359607 | farnesyl-diphosphate farnesyltransferase 1 | pyridine nucleotide-disulphide oxidoreductase domain 2; Probable oxidoreductase (By similarity) | 0.678 |
FDFT1 | RUSC1 | ENSP00000220584 | ENSP00000357336 | farnesyl-diphosphate farnesyltransferase 1 | RUN and SH3 domain containing 1; Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway | 0.699 |
IDI1 | COQ2 | ENSP00000370748 | ENSP00000310873 | isopentenyl-diphosphate delta isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | coenzyme Q2 homolog, prenyltransferase (yeast); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB | 0.428 |
IDI1 | FDFT1 | ENSP00000370748 | ENSP00000220584 | isopentenyl-diphosphate delta isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | farnesyl-diphosphate farnesyltransferase 1 | 0.848 |