node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDKRB1 | CXCL12 | ENSP00000216629 | ENSP00000379140 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | chemokine (C-X-C motif) ligand 12 | 0.902 |
BDKRB1 | GPR4 | ENSP00000216629 | ENSP00000319744 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | G protein-coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production | 0.900 |
BDKRB1 | GPR65 | ENSP00000216629 | ENSP00000267549 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | G protein-coupled receptor 65; Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation- induced cell death or differentiation of T-cells | 0.900 |
BDKRB1 | LPAR3 | ENSP00000216629 | ENSP00000359643 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins | 0.949 |
BDKRB1 | LPAR4 | ENSP00000216629 | ENSP00000362398 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | lysophosphatidic acid receptor 4; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA | 0.900 |
BDKRB1 | LPAR5 | ENSP00000216629 | ENSP00000327875 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | lysophosphatidic acid receptor 5; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities | 0.900 |
BDKRB1 | LPAR6 | ENSP00000216629 | ENSP00000344353 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | lysophosphatidic acid receptor 6 | 0.902 |
BDKRB1 | P2RY10 | ENSP00000216629 | ENSP00000171757 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | purinergic receptor P2Y, G-protein coupled, 10; Putative receptor for purines coupled to G-proteins | 0.900 |
CXCL12 | BDKRB1 | ENSP00000379140 | ENSP00000216629 | chemokine (C-X-C motif) ligand 12 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | 0.902 |
CXCL12 | EGFR | ENSP00000379140 | ENSP00000275493 | chemokine (C-X-C motif) ligand 12 | epidermal growth factor receptor | 0.513 |
CXCL12 | LPAR3 | ENSP00000379140 | ENSP00000359643 | chemokine (C-X-C motif) ligand 12 | lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins | 0.981 |
CXCL12 | LPAR5 | ENSP00000379140 | ENSP00000327875 | chemokine (C-X-C motif) ligand 12 | lysophosphatidic acid receptor 5; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities | 0.900 |
EGFR | CXCL12 | ENSP00000275493 | ENSP00000379140 | epidermal growth factor receptor | chemokine (C-X-C motif) ligand 12 | 0.513 |
EGFR | LPAR3 | ENSP00000275493 | ENSP00000359643 | epidermal growth factor receptor | lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins | 0.986 |
EGFR | PLD2 | ENSP00000275493 | ENSP00000263088 | epidermal growth factor receptor | phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) | 0.945 |
GPR4 | BDKRB1 | ENSP00000319744 | ENSP00000216629 | G protein-coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | 0.900 |
GPR4 | GPR65 | ENSP00000319744 | ENSP00000267549 | G protein-coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production | G protein-coupled receptor 65; Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation- induced cell death or differentiation of T-cells | 0.909 |
GPR4 | LPAR3 | ENSP00000319744 | ENSP00000359643 | G protein-coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production | lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins | 0.952 |
GPR4 | LPAR4 | ENSP00000319744 | ENSP00000362398 | G protein-coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production | lysophosphatidic acid receptor 4; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA | 0.905 |
GPR4 | LPAR5 | ENSP00000319744 | ENSP00000327875 | G protein-coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production | lysophosphatidic acid receptor 5; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities | 0.900 |