BRS3 protein (Homo sapiens) - STRING network view

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BRS3

bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (399 aa)

Predicted Functional Partners:

NMB

0.961

GRP

0.961

CCDC80

0.889

SRPX

0.860

PTK2

0.828

SLC4A1

0.596

C6orf89

0.505

NHLH2

0.499

NLE1

0.498

PIGA

0.483

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRS3	C6orf89	ENSP00000359682	ENSP00000347322	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	chromosome 6 open reading frame 89; Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells	0.505
BRS3	CCDC80	ENSP00000359682	ENSP00000206423	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	coiled-coil domain containing 80; Promotes cell adhesion and matrix assembly (By similarity)	0.889
BRS3	GRP	ENSP00000359682	ENSP00000256857	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	0.961
BRS3	NHLH2	ENSP00000359682	ENSP00000322087	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	nescient helix loop helix 2; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system	0.499
BRS3	NLE1	ENSP00000359682	ENSP00000413572	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	notchless homolog 1 (Drosophila)	0.498
BRS3	NMB	ENSP00000359682	ENSP00000378089	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	neuromedin B; Stimulates smooth muscle contraction in a manner similar to that of bombesin	0.961
BRS3	PIGA	ENSP00000359682	ENSP00000369820	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	phosphatidylinositol glycan anchor biosynthesis, class A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis	0.483
BRS3	PTK2	ENSP00000359682	ENSP00000341189	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...]	0.828
BRS3	SLC4A1	ENSP00000359682	ENSP00000262418	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1-1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin	0.596
BRS3	SRPX	ENSP00000359682	ENSP00000367794	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	sushi-repeat containing protein, X-linked; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction	0.860
C6orf89	BRS3	ENSP00000347322	ENSP00000359682	chromosome 6 open reading frame 89; Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	0.505
CCDC80	BRS3	ENSP00000206423	ENSP00000359682	coiled-coil domain containing 80; Promotes cell adhesion and matrix assembly (By similarity)	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	0.889
GRP	BRS3	ENSP00000256857	ENSP00000359682	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	0.961
GRP	NLE1	ENSP00000256857	ENSP00000413572	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	notchless homolog 1 (Drosophila)	0.471
GRP	NMB	ENSP00000256857	ENSP00000378089	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	neuromedin B; Stimulates smooth muscle contraction in a manner similar to that of bombesin	0.986
GRP	PTK2	ENSP00000256857	ENSP00000341189	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...]	0.924
NHLH2	BRS3	ENSP00000322087	ENSP00000359682	nescient helix loop helix 2; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	0.499
NLE1	BRS3	ENSP00000413572	ENSP00000359682	notchless homolog 1 (Drosophila)	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	0.498
NLE1	GRP	ENSP00000413572	ENSP00000256857	notchless homolog 1 (Drosophila)	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	0.471
NMB	BRS3	ENSP00000378089	ENSP00000359682	neuromedin B; Stimulates smooth muscle contraction in a manner similar to that of bombesin	bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	0.961

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