Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | GPR112 | G protein-coupled receptor 112; Orphan receptor (3080 aa) | ||||||||||||
Predicted Functional Partners:
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 | LRCH2 | leucine-rich repeats and calponin homology (CH) domain containing 2 (765 aa) |
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0.583 | ||||||||||
 | LAYN | layilin; Receptor for hyaluronate (374 aa) |
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0.574 | ||||||||||
 | CEP72 | centrosomal protein 72kDa; Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (647 aa) |
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0.567 | ||||||||||
 | SVEP1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (3571 aa) |
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0.504 | ||||||||||
 | EGFLAM | EGF-like, fibronectin type III and laminin G domains (1017 aa) |
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0.502 | ||||||||||
 | OR51E1 | olfactory receptor, family 51, subfamily E, member 1; Odorant receptor (Potential) (318 aa) |
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0.499 | ||||||||||
 | OR13H1 | olfactory receptor, family 13, subfamily H, member 1; Odorant receptor (Potential) (308 aa) |
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0.479 | ||||||||||
 | VEPH1 | ventricular zone expressed PH domain homolog 1 (zebrafish) (833 aa) |
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0.407 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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