node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CA12 | DNASE2B | ENSP00000178638 | ENSP00000359699 | carbonic anhydrase XII; Reversible hydration of carbon dioxide | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | 0.461 |
CRYAA | DNASE2B | ENSP00000291554 | ENSP00000359699 | crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | 0.533 |
CRYAA | HSF4 | ENSP00000291554 | ENSP00000264009 | crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions | heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription | 0.694 |
DNASE1L1 | DNASE2B | ENSP00000014935 | ENSP00000359699 | deoxyribonuclease I-like 1 | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | 0.481 |
DNASE2B | CA12 | ENSP00000359699 | ENSP00000178638 | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | carbonic anhydrase XII; Reversible hydration of carbon dioxide | 0.461 |
DNASE2B | CRYAA | ENSP00000359699 | ENSP00000291554 | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions | 0.533 |
DNASE2B | DNASE1L1 | ENSP00000359699 | ENSP00000014935 | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | deoxyribonuclease I-like 1 | 0.481 |
DNASE2B | H2AFV | ENSP00000359699 | ENSP00000308405 | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | 0.454 |
DNASE2B | H2AFZ | ENSP00000359699 | ENSP00000296417 | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | H2A histone family, member Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | 0.454 |
DNASE2B | HSF4 | ENSP00000359699 | ENSP00000264009 | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription | 0.897 |
DNASE2B | KLF1 | ENSP00000359699 | ENSP00000264834 | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...] | 0.609 |
DNASE2B | KPTN | ENSP00000359699 | ENSP00000337850 | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | kaptin (actin binding protein); May be involved in actin dynamics. May play a role in producing the sensory apparatus in hair cells. May play a role in actin rearrangements that accompany platelet activation and stereocilia formation | 0.533 |
DNASE2B | OR6N2 | ENSP00000359699 | ENSP00000344101 | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | olfactory receptor, family 6, subfamily N, member 2; Odorant receptor (Potential) | 0.455 |
DNASE2B | SKP1 | ENSP00000359699 | ENSP00000231487 | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.512 |
H2AFV | DNASE2B | ENSP00000308405 | ENSP00000359699 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | 0.454 |
H2AFZ | DNASE2B | ENSP00000296417 | ENSP00000359699 | H2A histone family, member Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | 0.454 |
HSF4 | CRYAA | ENSP00000264009 | ENSP00000291554 | heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription | crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions | 0.694 |
HSF4 | DNASE2B | ENSP00000264009 | ENSP00000359699 | heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | 0.897 |
KLF1 | DNASE2B | ENSP00000264834 | ENSP00000359699 | Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...] | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | 0.609 |
KPTN | DNASE2B | ENSP00000337850 | ENSP00000359699 | kaptin (actin binding protein); May be involved in actin dynamics. May play a role in producing the sensory apparatus in hair cells. May play a role in actin rearrangements that accompany platelet activation and stereocilia formation | deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation | 0.533 |