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TMCO3 TMCO3 TBC1D5 TBC1D5 NAB1 NAB1 CAMK2A CAMK2A SLC9A6 SLC9A6 CAMK2B CAMK2B NAB2 NAB2 CAMK2D CAMK2D CAMK2G CAMK2G CFTR CFTR SYT1 SYT1
"SLC9A6" - solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
SLC9A6solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (701 aa)    
Predicted Functional Partners:
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
        score_image   score_image   0.770
TBC1D5
TBC1 domain family, member 5; May act as a GTPase-activating protein for Rab family protein(s) (817 aa)
        score_image   score_image   0.766
TMCO3
transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity) (677 aa)
        score_image   score_image   0.748
CAMK2A
calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) (489 aa)
            score_image   0.701
CAMK2B
calcium/calmodulin-dependent protein kinase II beta (666 aa)
            score_image   0.701
CAMK2D
calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] (499 aa)
            score_image   0.701
CAMK2G
calcium/calmodulin-dependent protein kinase II gamma (556 aa)
            score_image   0.701
SYT1
synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 (422 aa)
            score_image   0.701
NAB1
NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) (487 aa)
            score_image   0.700
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity) (525 aa)
            score_image   0.700
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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