| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IFI27 | IFI35 | ENSP00000298902 | ENSP00000395590 | interferon, alpha-inducible protein 27; Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 | interferon-induced protein 35; Not yet known | 0.943 |
| IFI27 | IFI44 | ENSP00000298902 | ENSP00000359783 | interferon, alpha-inducible protein 27; Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 | interferon-induced protein 44; This protein aggregates to form microtubular structures (By similarity) | 0.545 |
| IFI27 | IFIT1 | ENSP00000298902 | ENSP00000360869 | interferon, alpha-inducible protein 27; Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 | interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5’-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2’-O-methylation of the 5’ cap and bear a 5’-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-se [...] | 0.947 |
| IFI27 | IFIT3 | ENSP00000298902 | ENSP00000360876 | interferon, alpha-inducible protein 27; Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 | interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1 [...] | 0.946 |
| IFI27 | IRF7 | ENSP00000298902 | ENSP00000329411 | interferon, alpha-inducible protein 27; Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 | interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent [...] | 0.942 |
| IFI27 | MX1 | ENSP00000298902 | ENSP00000381599 | interferon, alpha-inducible protein 27; Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 0.949 |
| IFI27 | OAS1 | ENSP00000298902 | ENSP00000388001 | interferon, alpha-inducible protein 27; Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 | 2’-5’-oligoadenylate synthetase 1, 40/46kDa | 0.947 |
| IFI27 | UBC | ENSP00000298902 | ENSP00000344818 | interferon, alpha-inducible protein 27; Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 | ubiquitin C | 0.572 |
| IFI35 | IFI27 | ENSP00000395590 | ENSP00000298902 | interferon-induced protein 35; Not yet known | interferon, alpha-inducible protein 27; Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 | 0.943 |
| IFI35 | IFI44 | ENSP00000395590 | ENSP00000359783 | interferon-induced protein 35; Not yet known | interferon-induced protein 44; This protein aggregates to form microtubular structures (By similarity) | 0.594 |
| IFI35 | IFIT1 | ENSP00000395590 | ENSP00000360869 | interferon-induced protein 35; Not yet known | interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5’-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2’-O-methylation of the 5’ cap and bear a 5’-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-se [...] | 0.943 |
| IFI35 | IFIT3 | ENSP00000395590 | ENSP00000360876 | interferon-induced protein 35; Not yet known | interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1 [...] | 0.947 |
| IFI35 | IRF7 | ENSP00000395590 | ENSP00000329411 | interferon-induced protein 35; Not yet known | interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent [...] | 0.948 |
| IFI35 | MX1 | ENSP00000395590 | ENSP00000381599 | interferon-induced protein 35; Not yet known | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 0.937 |
| IFI35 | OAS1 | ENSP00000395590 | ENSP00000388001 | interferon-induced protein 35; Not yet known | 2’-5’-oligoadenylate synthetase 1, 40/46kDa | 0.938 |
| IFI35 | RTP4 | ENSP00000395590 | ENSP00000259030 | interferon-induced protein 35; Not yet known | receptor (chemosensory) transporter protein 4 | 0.506 |
| IFI35 | UBC | ENSP00000395590 | ENSP00000344818 | interferon-induced protein 35; Not yet known | ubiquitin C | 0.483 |
| IFI44 | IFI27 | ENSP00000359783 | ENSP00000298902 | interferon-induced protein 44; This protein aggregates to form microtubular structures (By similarity) | interferon, alpha-inducible protein 27; Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 | 0.545 |
| IFI44 | IFI35 | ENSP00000359783 | ENSP00000395590 | interferon-induced protein 44; This protein aggregates to form microtubular structures (By similarity) | interferon-induced protein 35; Not yet known | 0.594 |
| IFI44 | IFIT1 | ENSP00000359783 | ENSP00000360869 | interferon-induced protein 44; This protein aggregates to form microtubular structures (By similarity) | interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5’-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2’-O-methylation of the 5’ cap and bear a 5’-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-se [...] | 0.612 |
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