| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CXCL16 | GIPC2 | ENSP00000293778 | ENSP00000359795 | chemokine (C-X-C motif) ligand 16; Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo | GIPC PDZ domain containing family, member 2 | 0.619 |
| CXCL16 | RGS19 | ENSP00000293778 | ENSP00000333194 | chemokine (C-X-C motif) ligand 16; Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo | regulator of G-protein signaling 19; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein | 0.900 |
| ELTD1 | GIPC2 | ENSP00000359778 | ENSP00000359795 | EGF, latrophilin and seven transmembrane domain containing 1; Could be involved in cardiac development | GIPC PDZ domain containing family, member 2 | 0.602 |
| FZD3 | FZD6 | ENSP00000240093 | ENSP00000351605 | frizzled family receptor 3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both p [...] | frizzled family receptor 6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both p [...] | 0.903 |
| FZD3 | GIPC2 | ENSP00000240093 | ENSP00000359795 | frizzled family receptor 3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both p [...] | GIPC PDZ domain containing family, member 2 | 0.866 |
| FZD6 | FZD3 | ENSP00000351605 | ENSP00000240093 | frizzled family receptor 6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both p [...] | frizzled family receptor 3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both p [...] | 0.903 |
| FZD6 | GIPC2 | ENSP00000351605 | ENSP00000359795 | frizzled family receptor 6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both p [...] | GIPC PDZ domain containing family, member 2 | 0.663 |
| GIPC2 | CXCL16 | ENSP00000359795 | ENSP00000293778 | GIPC PDZ domain containing family, member 2 | chemokine (C-X-C motif) ligand 16; Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo | 0.619 |
| GIPC2 | ELTD1 | ENSP00000359795 | ENSP00000359778 | GIPC PDZ domain containing family, member 2 | EGF, latrophilin and seven transmembrane domain containing 1; Could be involved in cardiac development | 0.602 |
| GIPC2 | FZD3 | ENSP00000359795 | ENSP00000240093 | GIPC PDZ domain containing family, member 2 | frizzled family receptor 3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both p [...] | 0.866 |
| GIPC2 | FZD6 | ENSP00000359795 | ENSP00000351605 | GIPC PDZ domain containing family, member 2 | frizzled family receptor 6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both p [...] | 0.663 |
| GIPC2 | GRIN1 | ENSP00000359795 | ENSP00000360608 | GIPC PDZ domain containing family, member 2 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.625 |
| GIPC2 | KDR | ENSP00000359795 | ENSP00000263923 | GIPC PDZ domain containing family, member 2 | kinase insert domain receptor (a type III receptor tyrosine kinase); Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an importan [...] | 0.615 |
| GIPC2 | LNX2 | ENSP00000359795 | ENSP00000325929 | GIPC PDZ domain containing family, member 2 | ligand of numb-protein X 2 | 0.687 |
| GIPC2 | RGS19 | ENSP00000359795 | ENSP00000333194 | GIPC PDZ domain containing family, member 2 | regulator of G-protein signaling 19; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein | 0.651 |
| GIPC2 | SEMA5A | ENSP00000359795 | ENSP00000371936 | GIPC PDZ domain containing family, member 2 | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collaps [...] | 0.559 |
| GIPC2 | ZBTB26 | ENSP00000359795 | ENSP00000362758 | GIPC PDZ domain containing family, member 2 | zinc finger and BTB domain containing 26; May be involved in transcriptional regulation | 0.599 |
| GRIN1 | GIPC2 | ENSP00000360608 | ENSP00000359795 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | GIPC PDZ domain containing family, member 2 | 0.625 |
| KDR | GIPC2 | ENSP00000263923 | ENSP00000359795 | kinase insert domain receptor (a type III receptor tyrosine kinase); Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an importan [...] | GIPC PDZ domain containing family, member 2 | 0.615 |
| LNX2 | GIPC2 | ENSP00000325929 | ENSP00000359795 | ligand of numb-protein X 2 | GIPC PDZ domain containing family, member 2 | 0.687 |
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