SLC44A5 protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Score

SLC44A5

solute carrier family 44, member 5 (719 aa)

Predicted Functional Partners:

CHAT

0.900

ACHE

0.900

TMEM163

0.705

ST6GALNAC5

0.520

LHFPL3

0.519

SLC25A27

0.513

SLC26A10

0.504

C8A

0.484

NABP1

0.483

NABP2

0.483

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACHE	CHAT	ENSP00000303211	ENSP00000337103	acetylcholinesterase	choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses	0.951
ACHE	SLC44A5	ENSP00000303211	ENSP00000359892	acetylcholinesterase	solute carrier family 44, member 5	0.900
C8A	LHFPL3	ENSP00000354458	ENSP00000444350	complement component 8, alpha polypeptide; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself	lipoma HMGIC fusion partner-like 3	0.478
C8A	SLC44A5	ENSP00000354458	ENSP00000359892	complement component 8, alpha polypeptide; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself	solute carrier family 44, member 5	0.484
CHAT	ACHE	ENSP00000337103	ENSP00000303211	choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses	acetylcholinesterase	0.951
CHAT	SLC44A5	ENSP00000337103	ENSP00000359892	choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses	solute carrier family 44, member 5	0.900
LHFPL3	C8A	ENSP00000444350	ENSP00000354458	lipoma HMGIC fusion partner-like 3	complement component 8, alpha polypeptide; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself	0.478
LHFPL3	SLC44A5	ENSP00000444350	ENSP00000359892	lipoma HMGIC fusion partner-like 3	solute carrier family 44, member 5	0.519
NABP1	NABP2	ENSP00000403683	ENSP00000267023	nucleic acid binding protein 1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...]	nucleic acid binding protein 2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...]	0.905
NABP1	SLC44A5	ENSP00000403683	ENSP00000359892	nucleic acid binding protein 1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...]	solute carrier family 44, member 5	0.483
NABP2	NABP1	ENSP00000267023	ENSP00000403683	nucleic acid binding protein 2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...]	nucleic acid binding protein 1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...]	0.905
NABP2	SLC44A5	ENSP00000267023	ENSP00000359892	nucleic acid binding protein 2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...]	solute carrier family 44, member 5	0.483
SLC25A27	SLC26A10	ENSP00000360398	ENSP00000320217	solute carrier family 25, member 27; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain	solute carrier family 26, member 10; Chloride/bicarbonate exchanger (By similarity)	0.406
SLC25A27	SLC44A5	ENSP00000360398	ENSP00000359892	solute carrier family 25, member 27; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain	solute carrier family 44, member 5	0.513
SLC26A10	SLC25A27	ENSP00000320217	ENSP00000360398	solute carrier family 26, member 10; Chloride/bicarbonate exchanger (By similarity)	solute carrier family 25, member 27; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain	0.406
SLC26A10	SLC44A5	ENSP00000320217	ENSP00000359892	solute carrier family 26, member 10; Chloride/bicarbonate exchanger (By similarity)	solute carrier family 44, member 5	0.504
SLC44A5	ACHE	ENSP00000359892	ENSP00000303211	solute carrier family 44, member 5	acetylcholinesterase	0.900
SLC44A5	C8A	ENSP00000359892	ENSP00000354458	solute carrier family 44, member 5	complement component 8, alpha polypeptide; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself	0.484
SLC44A5	CHAT	ENSP00000359892	ENSP00000337103	solute carrier family 44, member 5	choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses	0.900
SLC44A5	LHFPL3	ENSP00000359892	ENSP00000444350	solute carrier family 44, member 5	lipoma HMGIC fusion partner-like 3	0.519

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