| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD13C | FAM168B | ENSP00000359982 | ENSP00000374565 | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | 0.407 |
| ANKRD13C | GXYLT1 | ENSP00000359982 | ENSP00000381666 | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | glucoside xylosyltransferase 1; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose | 0.400 |
| ANKRD13C | MSL1 | ENSP00000359982 | ENSP00000462945 | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | male-specific lethal 1 homolog (Drosophila); Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at ’Lys-16’ (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at ’Lys-34’ (H2BK34Ub). This modification in turn stimulates histone H3 methylation at ’Lys-4’ (H3K4me) and ’Lys-79’ (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 | 0.406 |
| ANKRD13C | PTGDR | ENSP00000359982 | ENSP00000303424 | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | prostaglandin D2 receptor (DP); Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity) | 0.842 |
| ANKRD13C | PTGDR2 | ENSP00000359982 | ENSP00000332812 | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | prostaglandin D2 receptor 2; Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses | 0.652 |
| ANKRD13C | RNF220 | ENSP00000359982 | ENSP00000347548 | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | ring finger protein 220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity) | 0.408 |
| ANKRD13C | SLC10A7 | ENSP00000359982 | ENSP00000334594 | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | solute carrier family 10 (sodium/bile acid cotransporter family), member 7 | 0.414 |
| ANKRD13C | TCEANC2 | ENSP00000359982 | ENSP00000234827 | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | transcription elongation factor A (SII) N-terminal and central domain containing 2 | 0.408 |
| ANKRD13C | UBE2NL | ENSP00000359982 | ENSP00000359525 | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | ubiquitin-conjugating enzyme E2N-like | 0.416 |
| FAM168B | ANKRD13C | ENSP00000374565 | ENSP00000359982 | family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | 0.407 |
| FAM168B | SLC10A7 | ENSP00000374565 | ENSP00000334594 | family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | solute carrier family 10 (sodium/bile acid cotransporter family), member 7 | 0.400 |
| FAM168B | UBE2NL | ENSP00000374565 | ENSP00000359525 | family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | ubiquitin-conjugating enzyme E2N-like | 0.408 |
| GXYLT1 | ANKRD13C | ENSP00000381666 | ENSP00000359982 | glucoside xylosyltransferase 1; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | 0.400 |
| GXYLT1 | UBE2NL | ENSP00000381666 | ENSP00000359525 | glucoside xylosyltransferase 1; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose | ubiquitin-conjugating enzyme E2N-like | 0.404 |
| MSL1 | ANKRD13C | ENSP00000462945 | ENSP00000359982 | male-specific lethal 1 homolog (Drosophila); Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at ’Lys-16’ (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at ’Lys-34’ (H2BK34Ub). This modification in turn stimulates histone H3 methylation at ’Lys-4’ (H3K4me) and ’Lys-79’ (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | 0.406 |
| MSL1 | UBE2NL | ENSP00000462945 | ENSP00000359525 | male-specific lethal 1 homolog (Drosophila); Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at ’Lys-16’ (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at ’Lys-34’ (H2BK34Ub). This modification in turn stimulates histone H3 methylation at ’Lys-4’ (H3K4me) and ’Lys-79’ (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 | ubiquitin-conjugating enzyme E2N-like | 0.406 |
| PTGDR | ANKRD13C | ENSP00000303424 | ENSP00000359982 | prostaglandin D2 receptor (DP); Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity) | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | 0.842 |
| PTGDR | PTGDR2 | ENSP00000303424 | ENSP00000332812 | prostaglandin D2 receptor (DP); Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity) | prostaglandin D2 receptor 2; Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses | 0.720 |
| PTGDR2 | ANKRD13C | ENSP00000332812 | ENSP00000359982 | prostaglandin D2 receptor 2; Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses | ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER | 0.652 |
| PTGDR2 | PTGDR | ENSP00000332812 | ENSP00000303424 | prostaglandin D2 receptor 2; Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses | prostaglandin D2 receptor (DP); Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity) | 0.720 |
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